Store in cool and dry place,keep away from direct heat and light. Do not put in humid place like bathroom. Keep away from children and pet.
HOW TO USE: Take this medicine 2 times per day, normally in morning and evening.Take medicines by mouth with or without water. Put you tablet in small amount of water and dissolve it, when it dissolves drink whole mixture at once.
PHARMACOKINETICS:Bosentan have very low solubility so Bosentan absorbed when it taken in high amount. The drug binds with almost 98% of plasma protein. Bioavailability of this medicine is 505 and it is not affected by food. Half-life of Bosentan in health person is 5 hrs. The Bosentan excited by the biliary excretion.
SIDE EFFECTS OF BOSENTAN: Runny nose, dizziness, flushing and joint pain are the common side effects seen in the patients. If you see symptoms like swelling of ankles,fainting, weight gain, shortness of breath, fast heartbeat, weakness tell your doctor about this problems. This drug can effects on sperm production and also affect your ability to become father. The allergic reaction of Bosentan is rare.
PRECAUTION: Tell your doctor if you have allergic reaction towards the Bosentan.
Talk with your doctor if you have other disease like liver or kidney problems. This rug cause dizziness so kindly avoid driving and heavy exercise. Consumption of alcohol or cannabis can make you dizzier so kindly avoid it while taking the medicament. If you must not be taken in pregnancy because it can harms the unborn baby.
CDSCO APPROVAL: Bosentan (as monohydrate)Tablets 62.5mg/125mg approved by CDSCO in Indian in 23.06.2009.
FORMULATIONS AVAILABLE IN MARKET: Bosentan 62.5mg tablets
Bosentan 125mg tablets
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