DOMPERIDONE

Product Description

NiksanPharmaceutical is worlds leadingmanufacturer, trader, exporter and supplier of the Domperidone API and Domperidone formulations. Niksan Pharmaceutical manufactureslarge quantity of Domperidone API and finished products in Ankleshwar, Gujarat,India. Niksan Pharmaceutical and Niksan group companies are the largestmanufacturers and suppliers of Domperidone products.

NiksanPharmaceutical exporting very bigquantity of the fines quality products of Domperidone in all overworld for many years in a countries like Sri Lanka, Myanmar (Burma), Nepal,Indonesia, Philippines, Singapore, Canada, Bangladesh, Cambodia, New Zealand,Oman, Qatar, Kenya, United Arab Emirates, Pakistan, Sudan, Thailand, Ghana,Malaysia, ,Iraq, Jordan, France, Hong Kong, Lebanon , United Kingdom, SaudiArabia, Algeria, Belgium, Australia, Ireland, Kuwait, Italy, Taiwan, Nigeria,Vietnam, Iran, Egypt, United States, Morocco, South Africa, South Korea,Switzerland, Venezuela, Greece, Netherlands, Sweden, Mexico, Spain, Germany,Turkey, Brazil, Japan and many more countries.

Niksan Pharmaceutical also supplies large quantity of Domperidone products in Indian states like Gujarat, Haryana, Rajasthan, MadhyaPradesh, Bihar, Uttar Pradesh, Assam,Goa, Hyderabad, Telangana, Kerala,Tamilnadu, Delhi, Mizoram, Sikkim etc.

Domperidone belongs to the D2 receptor antagonist class ofmedicine. Domperidone mostly used as an antiemetic agent. It is also used asgalactagogue. The drug also used to prevent the nausea and vomiting.

SYNONYMS: Omperidona,Domperidone, Domperidonum.

IUPAC NAME:5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

CAS NO: 57808-66-9

FORMULA: C₂₂H₂₄ClN₅O₂

MOLECULAR MASS: 425.91g/mol 

STORAGE CONDITION: Store in room temperature in dry place. Keep away from direct sun lightand do not put in bathroom. Keep away from children and pet.

HOW TO TAKE: Take the medicine by mouth 30 min before taking the meals and at the bedtime. Do not take over dose this may cause side effects. Take your doctoradvice if you have any confusion about taking of dose.

HOW DOMPERIDONE WORKS: Domperidoneis the blocker of dopamine receptor. Domperidone blocks the dopamine receptorby this Domperidone cause pro lactic release in the body that inhibits thenausea and vomiting. Domperidone also delays the GI emptying.

PHARMACOKINETICS OFDOMPERIDONE: Domperidoneabsorbed rapidly in the body after the oral administration. Domperidone reachesthe peak plasma concentration in 1hr after the dosing. Domperidone binds withapproximately 91-93% of plasma protein. The half-lifeof Domperidone is 7 hours. The Domperidone takes time to eliminate from body;the 40mg dose of Domperidone takes 4 days to eliminate 31% of the metabolites.

SIDE EFFECTSOF DOMPERIDONE: The commonside effects of Domperidone are irritability, confusion, dry mouth, hotflushes, stomach cramp are seen in the patient. Tell your doctor immediately ifyou see effects like chest pain, irregular heartbeats, swelling of breast,difficulty in urination because this can cause very serious damage to yourbody. Menstrual changes and sexual difficulties are also found I the females.

PRECAUTIONS: Tell your doctor if you have allergies towards thedrug or have breast cancer. This medication taken in pregnancy if it clearlyneeded otherwise does not take the medication. Take your doctors advice beforebreast feeding the infants.

CDSCO APPROVAL: Cinnarizine + Domperidonetablets approved by CDSCO in India in1992- February,

Domperidone SR tab approvedby CDSCO in India in 16.01.2003,

Domperidone (10mg) +Activated dimethicone (125mg) chewable tablet approved by CDSCO in Indiain22.11.2005,

S(-) pantoprazole (assodium) 20mg (E.C.) + Domperidone SR 30mg tablet approved by CDSCO in India in30.08.2006,

Pantoprazole + DomperidoneSR approved by CDSCO in India in 24.12.2004,

Rabeprazole Sodium 20mg +Domperidone 30mg S.R Capsule approved by CDSCO in India in

04.10.2004,

Dexrabeprazole 10mg (EC) +Domperidone 30mg SR Capsules approved by CDSCO in India in 09.06.2008,

Omeprazole(20mg) Enteric coated + Domperidone(30mg) (S.R.) capsule approved by CDSCO in India in 10.03.2005,
Domperidone tablets/suspension/oral drops/rectalsuppositories approved by CDSCO in India in 1987-November,

Esomeprazole + DomperidoneSR capsules approved by CDSCO in India in 2004

FORMULATIONS AVAILABLE INMARKET:

Esomeprazole + DomperidoneSR capsules

Domperidone tablets

Domperidone suspension

Domperidone oral drops

Pantoprazole + DomperidoneSR tablets

Domperidone 10mg +Activated dimethicone 125mg chewable tablets

Omeprazole 20m) Entericcoated + Domperidone 30mg (S.R.) capsules

Domperidone rectalsuppositories

Note: Product protected by valid patents are not offered for sale incountries where such patents are still valid and its liability is at BuyersRisk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult