Cilostazol is part of a class of drugs known as platelet-aggregation inhibitors. The drug increases blood flow in the legs. As a vasodilator, it also has antiplatelet properties. It prevents blood cells from combining and inhibits the formation of blood clots. Because Cilostazol increases blood flow in the body, oxygen also flows through the body more effectively. It also helps blood flow freely throughout the body.
Niksan Pharmaceutical provides API and finished formulations of Cilostazol in allover Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh,Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam,Punjab, Delhi, Bihar, Jammu Kashmir Etc.
Niksan pharmaceutical is also large exporter of the API and finished pharmaceutical products of Cilostazol in many countries for years. The countries where we exporting are Puerto Rico, Brazil, Honduras, Argentina, Nicaragua, Philippines,Colombia, Guatemala, Uruguay, Mexico, Chile, Dominican Republic, Panama, SouthKorea, United States, El Salvador, Venezuela, Taiwan, Indonesia, Bolivia, Peru,Ecuador, Romania, Hong Ko ng, Thailand, United Arab Emirates, Iraq, Serbia,Spain, Bulgaria, Greece, Pakistan, Hungary, Portugal, Vietnam, Egypt, Iran,Poland, Czechia, Germany, Malaysia, Saudi Arabia, Canada, United Kingdom,Australia, Japan, Turkey, Italy and many more countries.
Cilostazol is belongs to drugs class called platelet-aggregation inhibitors. It is works by improving blood flow in legs. Cilostazol is anti-platelet type of drug and it also used as vasodilator.
Cilostazol stops blood cells to combine or stick together and inhibits blood clots. Cilostazol is used to increase the blood flow because of that the Oxygen flow in body also increases. Cilostazol is one type of vasodilators so it is also helps blood to flow smoothly in body.
SYNONYMS: Cilostazol,Cilostazole, Cilostazolum
IUPAC NAME: 6-[4-(1-cyclohexyl-1H-1, 2, 3, 4-tetrazol-5-yl) butoxy]-1, 2,3, 4-tetrahydroquinolin-2-one
CAS NO: 73963-72-1
MOLECULR MASS:369.46 g/mol
STORAGE: Store it in cool and dry place, away from moisture and direct light. Does not store this medicine in bathroom or any humidly place. Keep medicine away from the reach of children and pets.
APPLICATIONS: Cilostazol is widely used as vasodilator. Cilostazol is also use in the treatment of intermittent claudication. Cilostazol also use to treat cramp, ache, fatigue, classically it is used in calf muscle during the workout.
HOW TO USE: Follow all directions on your prescription label or as your doctor recommends you. Take Cilostazol two times per day on an empty stomach. Take medicine at least 45 minutes or 2 hours before meal. Cilostazol takes time like 8-12 weeks to improve your symptoms.But if your symptoms do not improve after 3-4 weeks treatments tell you doctor.Try to take medicine at a same time each day to improve effectiveness.
HOW CILOSTAZOL WORKS: Cilostazol and Cilostazol metabolites are one type of posphodiesterase III inhibitors (PDA III inhibitors). Cilostazol inhibits activity of posphodiesterase and also quash cAMP degradation so by that cAMP increased in Blood vessels and platelets and by this activity the platelet degradation inhibits and also blood clotting reduced by the activity
CONTRAINDICATIONS: Do not take Cilostazol medicati on if you have any heart problems like Congetive heart failure. Take your doctors advice if you are pregnant or in lactation phase. Cilostazol can harm nursing baby so do not take medication if you are breastfeeding a baby. Do not share your medication with other person. Take your doctors recommendation if any adverse reactions appear while taking the treatment of Cilostazol.
PHARMACOKINETICS: Absorption of Cilostazol in gastrointestinal system is slow or incomplete. Cilostazol is absorbed after the oral administration. A high fa tmeal can increase the absorption of Cilostazol. The half-life of the Cilostazol is between 11-13 hours. The Cilostazol excreted almost 74-76% by urination and the remaining medicine 23-27% eliminate by the faces like sweating or by skin.
SIDE EFFECTS OF CILOSTAZOL: The common side effects of Cilostazol are headache, upset bowel movements, runny nose,normal rash, dizziness. There are some major side effects are also cause by the Cilostazol like difficulty in breathing, chest pain, swelling of (face, tongue, fingers, and throat). Take your doctors instructions at the minute if you have symptoms like Fever, chills, body aches, flu symptoms. Paining while urinating or bloody urine Shortness of breath, swelling of feet and fingers
Chest pain, irregular heartbeats.
PRECAUTIONS: Do not take Cilostazol if you have heart problem. Cilostazol can make your problem worst. For the safety tell your doctor if you have any problem related liver or kidney. Avoid grapefruit juice or product. Do not take Cilostazol with Abacavir; it can increase the serum level. If Cilostazolis taken with Abciximab it can increase the severity of bleeding.
CDSCO APPOVAL: Cilostazol E.R. 100mg and 200mg tablets are approved by CDSCO in India in 30.10.2007.
FORMULATIONS AVAILABLE IN MARKET:
Cilostazole tablets 50mg (E.R. release)
Cilostazole tablets 100mg (E.R. release)
Cilostazol +L-Carnitine 100mg tablets
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