LERCANIDIPINE

Product Description

is a calcium channel blocker medicine used to treat high blood pressure(hypertension). If you have high blood pressure, taking lercanidipine helpsprevent heart disease, heart attacks and strokes.

SYNONYMS: Lercanidipine, Lercanidipino

IUPAC NAME: 3-{1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl}5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS NO: 100427-26-7

FORMULA: C₃₆H₄₁N₃O₆

MOLECULAR MASS:611.72 g/mol

STORAGE OF LERCANIDIPINE:Store below30°C. Protect from light and moisture. C08CA13 -lercanidipine; Belongs to the class of dihydropyridine derivative selectivecalcium-channel blockers with mainly vascular effects. Used in the treatment ofcardiovascular diseases.

APPLICATIONS OF LERCANIDIPINE:Lercanidipine is used to treat high blood pressure.Your GP may also prescribe it to prevent: heart disease. heart attacks.

HOW TO USE: It's best to take lercanidipine in themorning but you can take it at any time of day. Try to make sure you take it atthe same time every day. Takelercanidipine on an empty stomach, at least 15 minutes before a meal.

HOW LERCANIDIPINE WORKS: Lercanidipine isa type of medicine called a calcium channel blocker. Like other calcium channelblockers, lercanidipine works by blocking calcium going into muscles in the heart andblood vessels. Muscles need calcium to contract,so when you block the calcium, it makes the muscle cells relax and widen.

CONTRAINDICATIONS OF LERCANIDIPINE: Lercanidipine is contraindicated in patients with severe hepatic impairment or renalimpairment (GFR < 30 ml/min), including patients undergoing haemodialysis (see section 4.2 and section 4.3). Lercanidipinehas been associated with the development of cloudy peritoneal effluent inpatients on peritoneal dialysis.

PHARMACOKINETICS OF LERCANIDIPINE: Lercanidipineis slowly butcompletely absorbed from the gut. It has a totalbioavailability of 10% due to an extensive first-pass effect, or up to 40% iftaken after a fatty meal. Highest blood plasma levels are reached after 1.5 to3 hours.

SIDE EFFECTS OF LERCANIDIPINE:  Headaches. Make sure you rest and drinkplenty of fluids, Reddening of your face, neck or chest (flushing) This usuallyhappens when you first start taking lercanidipine, A fast, pounding orirregular heartbeat (palpitations), Swollen ankles (oedema)

PRECAUTIONS: Always take yourLercanidipine Clonmel tablets at least 15 minutes before a meal (breakfast).Alcohol intake may increase the effects and the side effects of lercanidipine.Therefore, youshould not drink alcohol during treatment.Grapefruit juice can increase the concentration of lercanidipine in your blood.

CDSCO APPROVAL:

Lercanidipine hcl 10MG tablets are approved by CDSCO in India in07/05/2002

FORMULATION AVAILABLEIN MARKET:

Lercanidipine HCL 10MG tablets

Lercanidipine HCL 20MG tablets

Note: Product protected by validpatents are not offered for sale in countries where such patents are stillvalid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult