DU LOXETINE

Product Description

is one of the biggest manufacturer, supplier, exporter and trader ofthe DULOXETINEfinished formulations moreover Duloxetine API. Niksan Pharmaceutical is the huge manufacturer, exporter andsupplier of Duloxetine API and formulation situated in Ankleshwar, Gujarat, India.

NiksanPharmaceutical is the suppliers, manufacturer, exporters and trader of
Duloxetine inthedomestic level as well as the international market.

Niksan is anIndian based pharmaceutical company so it also supplies and manufactures the Duloxetine to allIndian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, UttarPradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan,Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur,Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

NiksanPharmaceutical and Niksan group companies are exporters, suppliers andmanufacturers of the API and also Duloxetine formulations in many countries for many years. Niksanpharmaceutical currently exports Duloxetine API and Formulation to countries like New Zealand, Jordan,Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco,,Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel,Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland,Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and manyother countries.

DULOXETINEis aserotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment ofmajor depressive disorder, generalized anxiety disorder, diabetic peripheralneuropathic pain, fibromyalgia, and chronic musculoskeletal pain.

SYNONYSMS:Cymbalta

IUPAC NAME: (+)-(S)-N-methyl--(1-naphthyloxy)-2-thiophenepropylaminehydrochloride

CAS NO:136434-34-9

FORMULA:C18H19NOS

MOLECULAR MASS: 297.42g/mol

STORAGE CONDITIONS:Store at 20C to 25C (68F to 77F);excursions permitted between 15C to 30C (59F to 86F). Store in a dry placein tightly closed containers.

HOW TO USE:Duloxetine istypically taken once or twice daily with or without food. The starting dose isusually 30 mg to 60 mg once daily. Dosage can be adjusted by a healthcareprovider depending on the condition and patient response.

HOW DULOXETINEWORKS:Duloxetineworks by increasing the levels of serotonin and norepinephrine in the centralnervous system. These neurotransmitters are believed to have a positive effecton mood and pain perception, making Duloxetine effective for both mood and paindisorders.

PHARMACOKINETICSOF DULOXETINE:Duloxetine is well absorbed after oral administration, reaching peakplasma concentrations in 6 hours. It undergoes extensive hepatic metabolismprimarily via CYP1A2 and CYP2D6. The elimination half-life is approximately 12hours, and the drug is excreted in urine.

SIDE EFFECTSOF DULOXETINE: The normal side effects caused by Duloxetine Nausea, Dry mouth, Fatigue, Dizziness, Constipation, Insomnia, Increased blood pressure, Decreased appetite, Liver enzyme elevations (rare)

PRECAUTIONS: Use with caution inpatients with liver or kidney impairment, history of seizures, or those on MAOinhibitors. Gradual dose reduction is recommended when discontinuing. Monitorfor signs of suicidal thoughts, especially in adolescents and young adults.

CDSCOAPPROVAL:

Duloxetine hcl enteric coated tablets02/11/2004

Duloxetine HCl capsules 02/03/2005

Duloxetine HCl (60mg) tablet (additionalstrength) 28/02/2005

FORMULATIONSAVAILABLE IN MARKET:

DULOXETINE 20 MG Capsules

DULOXETINE 30 MG Capsules

DULOXETINE 40 MG Capsules

DULOXETINE 60 MG Capsules

DULOXETINE Tablets

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult