SILODOSIN

Product Description

Niksan Pharmaceutical is one of the leading manufacturer, supplier and exporterof the Silodosin. The best productmanufactured by Niksan Pharmaceutical is Silodosin. We manufacture, supply and export best quality product ofSilodosin API along withSilodosinformulations.

Niksan Pharmaceutical provides best quality product of Silodosinin all states of India like Kerala, Punjab, Rajasthan, Telangana, Bihar,Karnataka, Jammu and Kashmir, Maharashtra, West Bengal, Uttar Pradesh, Gujarat,Delhi, Tamil Nadu, Odisha, Madhya Pradesh, Andhra Pradesh, Haryana  and many other states.

NiksanPharmaceutical is also manufacture and exports large quantity of Silodosin products inwhole globe since many years in countries like Nepal, Taiwan, United ArabEmirates, Bangladesh, Iraq, Ireland, South Korea , Canada, Egypt, Indonesia,United States, Thailand, Philippines, Turkey, Nigeria, Australia, Germany,Malaysia, Vietnam, Spain, United Kingdom, Poland and many more countries.

Silodosin belongs to the alpha-blocker class of medicine. Silodosin used in thetreatment of enlarged prostate.

ENLARGED PROSTATE: Enlarged prostate cause difficulty in urination, pain full urination adalso cause trouble in urine urgency.

Silodosin also called alpha-adrenoceptor antagonist which is used in the treatmentof BPH.

SYNONYMS: Silodosin, Silodosina.

IUPAC NAME:1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2, 2,2-

Trifluoroethoxy) phenoxy] ethyll} amino) propyl] indoline-

7-carboxamide

CAS NO: 160970-54-7

FORMULA: C₂₅H₃₂F₃N₃O₄

MOLECULAR MASS:495.534 g/mol

STORAGE CONDITIONS: Store in cool and dry place, awayfrom light and heat. Do not put it in fridge or in bathroom. Keep away fromchildren and pet.

HOW TO USE: Take Silodosintablet/capsule orally with food one time per day. Take doctorsï advice beforetaking medicine. Silodosin comes in capsule so do not chew it or donït open it.

HOW SILODOSIN WORKS: Silodosin blocks the alpha A1 receptorswhich located in urethra and bladder. By blocking these receptors Silodosinrelaxes the smooth muscles and by this process the flow of urination improves.

PHARMACOKINETICS OF SILODOSIN: Normally Silodosinabsorbed by the gut. The AUC and peak plasma level may effected by the food.The bio avaibility of Silodosin is 32%. The metabolism of Silodosin is done inliver. The half-life of Silodosin is approximately 13.3ï8.07 hrs. The rout ofelimination of Silodosin is renal 33.5% and by faecal 54.9%.

SIDE EFFECTS OF SILODOSIN: The side effects ofSilodosin are ejaculation problem, fainting, headache, dizziness, lightheadedness. If you have side effect like fainting or weakness contact yourdoctor and take advice. There are some rare side effects like rash, allergy,and redness of skin, itching or trouble in breathing.

PRECAUTIONS OF SILODOSIN: Tell your pharmacistif you have any allergic reaction to the Silodosin. Also tell your doctor ifyou have any disease related to lung, heart, liver or kidney. Do not drive oruse any machinery because Silodosin makes you dizzy. Take less amount ofalcohol and also if you are using cannabis talk to your doctor about using it

CDSCO APPROVAL: SilodosinCapsules2mg/4mg/8mg approved by CDSCO in India in 23.06.2011

Silodosin Tablets 4mg approved by CDSCO inIndian in 10.04.2012

FORMULATIONS AVAILABLE IN MARKET:

Silodosin 2 mg capsules

Silodosin 4mg capsules

Silodosin 8mg capsules

Silodosin 4 mg tablets

Silodosin 8 mg tablets

Silodosin 4mg + Dutasteride 0.5mg tablets

Silodosin 8mg + Dutasteride 0.5mg tablets

Note: Product protected by validpatents are not offered for sale in countries where such patents are stillvalid and its liability is at Buyers Risk.

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult