SILODOSIN

Product Description

Niksan Pharmaceutical is one of the leading manufacturer, supplier and exporterof the Silodosin. The best productmanufactured by Niksan Pharmaceutical is Silodosin. We manufacture, supply and export best quality product ofSilodosin API along withSilodosinformulations.

Niksan Pharmaceutical provides best quality product of Silodosinin all states of India like Kerala, Punjab, Rajasthan, Telangana, Bihar,Karnataka, Jammu and Kashmir, Maharashtra, West Bengal, Uttar Pradesh, Gujarat,Delhi, Tamil Nadu, Odisha, Madhya Pradesh, Andhra Pradesh, Haryana  and many other states.

NiksanPharmaceutical is also manufacture and exports large quantity of Silodosin products inwhole globe since many years in countries like Nepal, Taiwan, United ArabEmirates, Bangladesh, Iraq, Ireland, South Korea , Canada, Egypt, Indonesia,United States, Thailand, Philippines, Turkey, Nigeria, Australia, Germany,Malaysia, Vietnam, Spain, United Kingdom, Poland and many more countries.

Silodosin belongs to the alpha-blocker class of medicine. Silodosin used in thetreatment of enlarged prostate.

ENLARGED PROSTATE: Enlarged prostate cause difficulty in urination, pain full urination adalso cause trouble in urine urgency.

Silodosin also called alpha-adrenoceptor antagonist which is used in the treatmentof BPH.

SYNONYMS: Silodosin, Silodosina.

IUPAC NAME:1-(3-hydroxypropyl)-5-[(2R)-({2-[2-[2-(2, 2,2-

Trifluoroethoxy) phenoxy] ethyll} amino) propyl] indoline-

7-carboxamide

CAS NO: 160970-54-7

FORMULA: C₂₅H₃₂F₃N₃O₄

MOLECULAR MASS:495.534 g/mol

STORAGE CONDITIONS: Store in cool and dry place, away from lightand heat. Do not put it in fridge or in bathroom. Keep away from children andpet.

HOW TO USE: Take Silodosintablet/capsule orally with food one time per day. Take doctors’ advice beforetaking medicine. Silodosin comes in capsule so do not chew it or don’t open it.

HOW SILODOSIN WORKS: Silodosin blocks the alpha A1 receptorswhich located in urethra and bladder. By blocking these receptors Silodosinrelaxes the smooth muscles and by this process the flow of urination improves.

PHARMACOKINETICS OF SILODOSIN: Normally Silodosinabsorbed by the gut. The AUC and peak plasma level may effected by the food.The bio avaibility of Silodosin is 32%. The metabolism of Silodosin is done inliver. The half-life of Silodosin is approximately 13.3±8.07 hrs. The rout ofelimination of Silodosin is renal 33.5% and by faecal 54.9%.

SIDE EFFECTS OF SILODOSIN: The side effects of Silodosin areejaculation problem, fainting, headache, dizziness, light headedness. If youhave side effect like fainting or weakness contact your doctor and take advice.There are some rare side effects like rash, allergy, and redness of skin,itching or trouble in breathing.

PRECAUTIONS OF SILODOSIN: Tell your pharmacist if you have anyallergic reaction to the Silodosin. Also tell your doctor if you have anydisease related to lung, heart, liver or kidney. Do not drive or use any machinerybecause Silodosin makes you dizzy. Take less amount of alcohol and also if youare using cannabis talk to your doctor about using it

CDSCO APPROVAL: SilodosinCapsules2mg/4mg/8mg approved by CDSCO in India in 23.06.2011

Silodosin Tablets 4mg approved by CDSCO inIndian in 10.04.2012

FORMULATIONS AVAILABLE IN MARKET:

Silodosin 2 mg capsules

Silodosin 4mg capsules

Silodosin 8mg capsules

Silodosin 4 mg tablets

Silodosin 8 mg tablets

Silodosin 4mg + Dutasteride 0.5mg tablets

Silodosin 8mg + Dutasteride 0.5mg tablets

Note: Product protected by valid patents are notoffered for sale in countries where such patents are still valid and itsliability is at Buyers Risk.

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult