SUMATRIPTAN SUCCINATE

Product Description

is one of the biggest manufacturer, supplier, exporter and trader ofthe SUMATRIPTAN SUCCINATEfinished formulations moreover SUMATRIPTAN SUCCINATE API. Niksan Pharmaceutical is the huge manufacturer, exporter andsupplier of SumatriptanSuccinate API and formulation situated inAnkleshwar, Gujarat, India.

NiksanPharmaceutical is the suppliers, manufacturer, exporters and trader of
Sumatriptan Succinate inthe domestic level as well as the internationalmarket.

 

Niksan is anIndian based pharmaceutical company so it also supplies and manufactures the Sumatriptan Succinate to allIndian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, UttarPradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan,Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur,Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

 

NiksanPharmaceutical and Niksan group companies are exporters, suppliers andmanufacturers of the API and also Sumatriptan Succinate formulations in many countries for manyyears. Niksan pharmaceutical currently exports Sumatriptan Succinate API and Formulation to countries like NewZealand, Jordan, Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong,Morocco, Portugal, France, South Africa, Philippines, Malaysia, Singapore,Israel, Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea,Switzerland, Algeria, Pakistan, Canada, Vietnam, United States, Germany, Braziland many other countries.

 

SUMATRIPTANSUCCINATEbelongs to a group of medicines called triptans, or serotonin (5-HT1)agonists. We do not yet understand what causes migraines and cluster headaches.However, your symptoms may be due to the temporary widening of blood vessels inyour head.

 

SYNONYSMS: Sumatriptanum , Sumatriptan hydrogen succinate ,Migratriptan , Sumatriptan , Imitrex Oral , Treximet ,GR43175 

 

IUPAC NAME: 1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide; butanedioicacid

 

CAS NO:103628-48-4

 

FORMULA:C14H21N3O2S C4H6O4

 

MOLECULAR MASS:  413.49g/mol

 

STORAGE CONDITIONS:Sumatriptan succinate should be storedat room temperature, away from heat, moisture, and direct light. Itscrucial to keep the container tightly closed and stored in a cool,well-ventilated area. Avoid storing it near sources of ignition or incompatiblematerials like strong acids or bases. 

 

HOW TO USE: Usually inject itinto your thigh. The medicine generally works in 10 to 15 minutes. If yourheadache improves but then comes back, you can inject another dose after 1hour. If the first sumatriptan injection does not help, do not have another onefor the same attack.

 

HOW SUMATRIPTANSUCCINATE WORKS:Sumatriptan acts as an agonist on 5-HT1B/1D receptors by inducingvasoconstriction in the basilar artery and blood vessels within the dura mater.The drug reduces peripheral nociception either by selective cranialvasoconstriction or by affecting trigeminovascular nerves.

 

PHARMACOKINETICSOF SUMATRIPTAN SUCCINATE:Sumatriptan has a volume of distribution of 508L for a 6mg subcutaneousdose ⁷, or 2.7L/kg. Sumatriptan is 14%-21% bound to protein incirculation. Sumatriptan is predominantly metabolized by monoamine oxidaseA ^{7,10,8,10,5,9}. The main metabolites are the inactive indoleacetic acid and indole acetic acid glucuronide.

 

SIDE EFFECTS OF SUMATRIPTAN SUCCINATE: The normal side effects caused by SUMATRIPTANSUCCINATE are flushing, tingling feeling, feeling warm or cold, drowsiness, tiredness,weakness, dizziness, upset stomach, diarrhea, nausea, muscle cramps.

 

PRECAUTIONS: Tell your doctorif you are allergic to the medicine. Sumatriptan should not be taken while youare using certain other medicines. Before taking sumatriptan, tell yourhealthcare provider about any prescription or over-the-counter (OTC) medicines,vitamins/minerals, herbal products, and other supplements you are using.

 

 

FORMULATIONSAVAILABLE IN MARKET:

SUMATRIPTAN SUCCINATE 50 MG tablets

SUMATRIPTAN SUCCINATE 100 MG tablets

SUMATRIPTAN SUCCINATE Injection 5 MG/0.5 ML

 

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

 

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult

Therapeutic Application

Sumatriptan succinate is a pharmaceutical compound classed as a serotonin receptor agonist. It is widely employed to address migraine headaches by targeting specific receptors in the brain, which constrict blood vessels and alleviate pain. This rapid action makes it a highly sought-after solution for acute migraine relief among adults.


Quality and Purity Standards

With a purity of 99%, Sumatriptan succinate is produced adhering to stringent quality controls. Its physical form as a fine powder ensures consistent dosing, while compliance with applicable health and safety standards in India guarantees product reliability. Manufacturers and distributors offer documentation including molecular data and certificate of analysis for professional users.


Physical and Chemical Properties

Sumatriptan succinate presents as a white to off-white powder, highly soluble in water, with a pH of approximately 4.9 and a melting point of 165-169C. Used in pharmaceutical formulations, Sumatriptans molecular formula is C14H21N3O2S. Its particle size ranges between 630-679 nm, facilitating rapid dissolution and consistent performance in medicinal applications.