RIVAROXABAN

Product Description

Niksan Pharmaceutical is leading manufacturer and distributer of the Rivaroxaban among the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Rivaroxaban API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Rivaroxaban in the domestic level as well as the international market. 

Niksan Pharmaceutical provides Rivaroxaban API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Rivaroxaban API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Rivaroxaban is  a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps prevent harmful clots from forming in the blood vessels. This medicine is available only with your doctor's prescription.

SYNONYMS: Rivaroxaban

IUPAC NAME: 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide

CAS NO: 366789-02-8

FORMULA: C19H18ClN3O5S

MOLECULAR MASS: 435.88 g/mol

STORAGE OF RIVAROXABAN: Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

APPLICATIONS OF RIVAROXABAN: Rivaroxaban is used to treat deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung) in adults. Rivaroxaban is also used to prevent DVT and PE from happening again after initial treatment is completed in adults

HOW TO USE: You'll usually take rivaroxaban once a day just after a meal or snack. It's important to take it with some food to help your body absorb the whole dose. Try to take it at the same time every day.

HOW RIVAROXABAN WORKS: Clotting factors are made by the liver and help stop bleeding. They work with blood cells called platelets that trigger the clotting process to make sure your blood clots properly. Rivaroxaban works by stopping a clotting factor called factor Xa from working. This thins your blood so it takes longer to clot.

CONTRAINDICATIONS OF RIVAROXABAN:  Severe hypersensitivity to rivaroxaban (or any component of the formulation) can occur. Hematologic: Active pathological bleeding is a contraindication for rivaroxaban use. Rivaroxaban should not be taken during pregnancy. If you take rivaroxaban and are planning to get pregnant or you become pregnant while taking it, speak to your doctor or specialist. You will need to be changed to a different medicine.

PHARMACOKINETICS OF RIVAROXABAN: rivaroxaban is rapidly absorbed and reaches peak plasma concentration in 2-4 hours. Bioavailability of the 10 mg dose is >80%. However, the 15-20 mg dose have a lower bioavailability if taken in the fasted state and consequently should be taken with food.

SIDE EFFECTS OF RIVAROXABAN:  Oral anticoagulants can cause serious kidney damage. This side effect is called anticoagulant-related nephropathy (ARN) and results from bleeding in the kidneys. Although this side effect is rare, it is serious and can be life-threatening.most common side effect is bleeding gums, Back pain, bloody stools, bowel or bladder dysfunction, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, coughing up blood, difficulty with breathing or swallowing, dizziness.

PRECAUTIONS: You may bleed or bruise more easily while you are using this medicine. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Be careful when using sharp objects, including razors and fingernail clippers. Avoid nose picking and forceful nose blowing.

CDSCO APPROVAL:

Rivaroxaban 10MG Tablet are approved by CDSCO in India in 03.02.10

FORMULATION AVAILABLE IN MARKET:

Rivaroxaban 10 MG Tablet

Rivaroxaban 15 MG Tablet

Rivaroxaban 20 MG Tablet

Rivaroxaban 2.5 MG Tablet

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult