AMANTADINE

Product Description

is one of the biggest manufacturer, supplier, exporter and trader ofthe AMANTADINEfinished formulations moreover AMANTADINE API. Niksan Pharmaceutical is the huge manufacturer, exporter andsupplier of AMANTADINE API and formulation situated in Ankleshwar, Gujarat, India.

NiksanPharmaceutical is the suppliers, manufacturer, exporters and trader of
AMANTADINE inthedomestic level as well as the international market.

Niksan is anIndian based pharmaceutical company so it also supplies and manufactures the AMANTADINE to allIndian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, UttarPradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan,Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur,Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

NiksanPharmaceutical and Niksan group companies are exporters, suppliers andmanufacturers of the API and also AMANTADINE formulations in many countries for many years. Niksanpharmaceutical currently exports AMANTADINE API and Formulation to countries like New Zealand, Jordan,Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco,,Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel,Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland,Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and manyother countries.

AMANTADINEis an antiviral andantiparkinsonian medication. Initially developed to prevent and treat influenzaA, it is now also used in the management of Parkinson’s disease anddrug-induced extrapyramidal symptoms.

SYNONYSMS:1-Adamantanamine, Symmetrel

IUPAC NAME: 1-Adamantanamine

CAS NO:768-94-5

FORMULA:C10H17N

MOLECULAR MASS:  151.25 g/mol

STORAGE CONDITIONS:Store at room temperature between 20°C to25°C (68°F to 77°F). Protect from moisture and light. Keep container tightlyclosed.

HOW TO USE:

For Influenza A prophylaxis/treatment:100 mg orally twice daily for adults; 100 mg daily for elderly or renalimpairment.
FOR Parkinson’s disease: Initial dose is usually 100 mg once daily,increasing to 100 mg twice daily after 1 week.
Follow your doctor’s prescription carefully.

HOW AMANTADINEWORKS:Amantadineworks by blocking the M2 proton channel of the influenza A virus, preventingviral uncoating inside host cells.
In Parkinson’s disease, it enhances dopamine release, blocks dopamine reuptake,and exerts mild anticholinergic effects, improving motor symptoms.

PHARMACOKINETICSOF AMANTADINE: AMANTADINE Well absorbed orally. idely distributed, crosses the blood-brainbarrier. Minimal hepatic metabolism. Primarily excreted unchanged by thekidneys. 10–15 hours (may be longer in elderly or renal impairment).

SIDE EFFECTSOF AMANTADINE:

Common: Nausea, dizziness, insomnia, dry mouth,constipation.
Serious: Hallucinations, confusion, orthostatic hypotension, livedoreticularis, seizures.

PRECAUTIONS: Avoid suddendiscontinuation in Parkinson’s patients (may worsen symptoms). Use cautiouslyin elderly, renal impairment, seizure disorders, and psychiatric conditions.May cause drowsiness—avoid driving if affected.

CDSCOAPPROVAL:

Amantadine Hydrochloride 1972-December

FORMULATIONSAVAILABLE IN MARKET:

Amantadine 100 mg Capsules

Amantadine Hydrochloride Oral Solution

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult