Letrozole belongs to aromatase inhibitors class ofmedicine. Letrozole works by stopping the growth of breast cancer cell whichneeds estrogen to grow. Letrozole inhibits the estrogen level in body.
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SYNONYSMS: Letrozole, Letrozol
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IUPAC NAME:4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile
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CAS NO: 112809-51-5
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FORMULA: C17H11N5
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MOLECULAR MASS: 285.30Â g/mol
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STORAGE CONDITIONS: Store the medicine in room temperature and dry place. Placethe medication away from direct heat and light. Do not keep medicine inbathroom or humid place. Keep away from children and pets.
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HOW TO USE: Take themedicine orally once a day with or without food. Take medicine with milk orfood if you feel stomach upset. Take medication regularly to get most benefitsof it.
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HOW LETROZOLE WORKS: Letrozole blocks the active site ofelectron transfer chain of CYP19A1. By this Letrozole inhibits the conversionof estrogen form androgen. By this Letrozole stops the growth of cancer cellswhich needs estrogen to grow.
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PHARMACOKINETICS: Letrozole absorbed rapidly in body afteroral administration. Letrozole takes 8.10hpurs to reach peak plasmaconcentration. The bioavaibility of Letrozole is 99.9%. Almost 60% of medicinebinds with the plasma proteins. The half-life of this medicine is 42hours. Almost90% of Letrozole eliminated through urine.
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SIDE EFFECTS OF LETROZOLE: The common side effects of Letrozole areheadache, nausea, vomiting, dizziness, sweating, tiredness, joint and musclepain. Tell your doctor if you see side effects like hot flushes, hair loss,bone fracture, swelling of arms or feet, blurred vision, dark urine. Seekimmediate medical attention if you see side effects like blood in cough,shortness of breath, arm or leg pain, stomach pain, dizziness, fainting, hairloss, vision change and sudden headache.
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PRECAUTIONS: Tell your doctor if you have allergicreaction to the Letrozole medicine.
Tell your doctor if youhave history like heart disorder, liver problem, high BP, strokes, blood clotproblems. This drug makes you dizzy and because blurred vision so kindly avoiddriving, exercise, and operating machineries. Do not consume alcohol ormarijuana while taking the medicine.
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CDSCO APPROVAL:LapatinibDitosylate Tablets 250mg (addl. Indication) approved by CDSCO in India in 10.05.2010
Letrozole 2.5mg tablet (additional indication) approved by CDSCO in India in28.12.2004
 Letrozole approved by CDSCOin India in 11.02.2002
 Palbociclib Capsules75mg/100mg/125 mg approved by CDSCO in India in11.08.2016
 Letrozole tabs approved byCDSCO in India in12.03.1998
Letrozole 2.5mg tablet (for additional indication)approved byCDSCO in India in 10.04.2007
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FORMULATIONS AVAILABLE IN MARKET:
Letrozole 5mg tablets
Letrozole 2.5 mgtablets
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Note: Product protected by valid patents are notoffered for sale in countries where such patents are still valid and itsliability is at Buyers Risk
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REFERENCES:
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www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult
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