GLICLAZIDE

Product Description

is one of the biggest manufacturer, supplier, exporter and trader ofthe GLICLAZIDEfinished formulations moreover Gliclazide API. Niksan Pharmaceutical is the huge manufacturer, exporter andsupplier of Gliclazide API and formulation situated in Ankleshwar, Gujarat, India.

NiksanPharmaceutical is the suppliers, manufacturer, exporters and trader of
Gliclazide inthedomestic level as well as the international market.

 

Niksan is anIndian based pharmaceutical company so it also supplies and manufactures the Gliclazide to allIndian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, UttarPradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan,Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur,Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.  

 

NiksanPharmaceutical and Niksan group companies are exporters, suppliers andmanufacturers of the API and also Gliclazide formulations in many countries for many years. Niksanpharmaceutical currently exports Gliclazide API and Formulation to countries like New Zealand, Jordan,Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco,Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel,Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland,Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and manyother countries.

 

GLICLAZIDEis an oralantihyperglycemic agent, specifically categorized as a sulfonylurea. It isused to treat type 2 diabetes by stimulating the pancreas to release moreinsulin. Furthermore, gliclazide is classified as a second-generationsulfonylurea, alongside other drugs like glibenclamide and glipizide. Italso falls under the BCS Class II drug category due to its lowsolubility and high permeability. 

 

SYNONYSMS:Glimicron, Gliclazida, Diamicron

 

IUPAC NAME: 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

 

CAS NO:21187-98-4

 

FORMULA:C15H21N3O3S

 

MOLECULAR MASS:  323.412 g/mol

 

STORAGE CONDITIONS:Store this medication at roomtemperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat,light and moisture. Do not store in the bathroom. Keep this and all medicationsout of the reach of children. MEDICAL ALERT: Your condition can causecomplications in a medical emergency.

 

HOW TO USE:Swallow yourgliclazide tablets whole with a drink of water. Do not chew them. If you aretaking 2 doses a day, take 1 dose with your breakfast and 1 dose with yourevening meal. If you are taking slow-release gliclazide, take your dose once aday with breakfast.

HOW GLICLAZIDEWORKS:Gliclazide, a sulfonylurea, helps lowerblood sugar in people with type 2 diabetes by stimulatingthe pancreas to release more insulin. It also improves the body'ssensitivity to insulin, making it more effective at controlling glucoselevels. Essentially, it helps the body use insulin more efficiently andeffectively. 

 

PHARMACOKINETICSOF GLICLAZIDE:Gliclazide is a sulphonylurea drug with an intermediate half-lifeof around 11 hours. It is extensively metabolised, and renal clearance accountsfor only 4% of total drug clearance. The molecule contains an azabicyclo-octylgroup which confers special properties on the basic sulphonylurea moiety.

 

SIDE EFFECTSOF GLICLAZIDE:Stomach ache or indigestion, Feeling sick (nausea) , Being sick(vomiting), frequent sips of water or squash to avoid dehydration, Diarrhoea, Drinklots of fluids, Constipation.

 

PRECAUTIONS: Tell yourdoctor if you are allergic to the medicine. Ask your doctor’s advice if youhave medical history like diabetes, heart problem, liver problem, kidney disease,breast cancer or tumour. If you are taking the other medication kindly tellyour doctor about it. Avoid combination with alcohol, Don’t Take This Medicine During Pregnancy& Breast-Feeding.

 

CDSCOAPPROVAL:

Gliclazide modified release tablet 14.08.07

Gliclazide tablets 1988-November

Gliclazide modified release tabs. 09.11.2000

Gliclazide M.R. (30mg/60mg) + Metformin HCl (500mg) ER Tablet27/04/2005

Gliclazide 40mg/80mg + MetFormin Hcl 500mg + Rosiglitazone 2mgtablet 22/08/2006

Metformin SR 500mg/500mg + GliclazideSR 60mg/30mg + Pioglitazone15mg/15mg tablets 28.05.10

Gliclazide 40/80mg+Metformin 500mg+Pioglitazone15mg 19.07.10

FORMULATIONSAVAILABLE IN MARKET:

GLICLAZIDE 30 MG tablets

GLICLAZIDE 40 MG tablets

GLICLAZIDE 60 MG tablets

GLICLAZIDE 80 MG tablets

 

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

 

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com