CILOSTAZOL IP & CILOSTAZOL USP

Product Description

NiksanPharmaceutical provides APIand finished formulations of Cilostazol in allover Indian States Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh,Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam,Punjab, Delhi, Bihar, Jammu Kashmir Etc.

Niksanpharmaceutical is alsolarge exporter of the API and finished pharmaceutical products of Cilostazol in manycountries for years. The countries where we exporting are Puerto Rico, Brazil,Honduras, Argentina, Nicaragua, Philippines, Colombia, Guatemala, Uruguay,Mexico, Chile, Dominican Republic, Panama, South Korea, United States, ElSalvador, Venezuela, Taiwan, Indonesia, Bolivia, Peru, Ecuador, Romania, Hong Kong,Thailand, United Arab Emirates, Iraq, Serbia, Spain, Bulgaria, Greece,Pakistan, Hungary, Portugal, Vietnam, Egypt, Iran, Poland, chia, Germany,Malaysia, Saudi Arabia, Canada, United Kingdom, Australia, Japan, Turkey, Italyand many more countries.

Cilostazol is belongs to drugs classcalled platelet-aggregation inhibitors. It is works by improving bloodflow in legs. Cilostazol is anti-platelet type of drug and it also used asvasodilator.

Cilostazol stops blood cells to combine or sticktogether and inhibits blood clots. Cilostazol is used to increase the bloodflow because of that the Oxygen flow in body also increases. Cilostazol is onetype of vasodilators so it is also helps blood to flow smoothly in body.

SYNONYMS: Cilostazol,Cilostazole, Cilostazolum

IUPAC NAME: 6-[4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy]-1,2,3, 4-tetra hydro quinolin-2-one

CAS NO: 73963-72-1

FORMULA: C₂₀H₂₇N₅O₂

MOLECULRMASS:369.46 g/mol

STORAGE: Store it in cool and dry place, away from moistureand direct light. Does not store this medicine in bathroom or any humidly place.Keep medicine away from the reach of children and pets.

APPLICATIONS: Cilostazol is widely used as vasodilator. Cilostazol isalso use in the treatment of intermittent claudication. Cilostazol alsouse to treat cramp, ache, fatigue, classically it is used in calf muscle duringthe workout.

HOW TO USE: Follow all directions on your prescriptionlabel or as your doctor recommends you. Take Cilostazol two times per day on anempty stomach. Take medicine at least 45 minutes or 2 hours before meal. Cilostazol takes time like 8-12 weeks to improve yoursymptoms. But if your symptoms do not improve after 3-4 weeks treatments tellyou doctor. Try to take medicine at a same time each day to improveeffectiveness.

HOWCILOSTAZOL WORKS: Cilostazol metabolites are one type of phosphodiesteraseIII inhibitors (PDA III inhibitors). Cilostazol inhibits activity of phosphodiesterase and also quash CAMP degradationso by that CAMP increased in Blood vessels and platelets and by this activitythe platelet degradation inhibits and also blood clotting reduced by theactivity

CONTRAINDICATIONS: Do not take Cilostazol medicati on if youhave any heart problems like Congetive heart failure. Take your doctor’s adviceif you are pregnant or in lactation phase. Cilostazol can harm nursing baby so do not take medication if you are breastfeedinga baby. Do not share your medication with other person. Take your doctor’s recommendationif any adverse reactions appear while taking the treatment of Cilostazol.

PHARMACOKINETICS: Absorptionof Cilostazol in gastrointestinal system is slow orincomplete. Cilostazol is absorbed after the oral administration. Ahigh fa meal can increase the absorption of Cilostazol. Thehalf-life of the Cilostazol is between11-13 hours. The Cilostazol excreted almost 74-76% by urination and theremaining medicine 23-27% eliminate by the faces like sweating or by skin.

SIDE EFFECTSOF CILOSTAZOL: The common side effects of Cilostazol are headache, upset bowel movements, runnynose, normal rash, dizziness. There are some major side effects are also causeby the Cilostazol like difficulty in breathing, chest pain, swellingof (face, tongue, fingers, and throat). Take your doctors instructions at theminute if you have symptoms like Fever, chills, body aches, flu symptoms.Paining while urinating or bloody urine Shortness of breath, swelling of feetand fingers Chest pain, irregular heartbeats.

PRECAUTIONS: Do not take Cilostazol if you have heart problem. Cilostazol can make your problem worst. For the safetytell your doctor if you have any problem related liver or kidney. Avoid grapefruitjuice or product. Do not take Cilostazol with Batcaver it can increase the serum level. If Cilostazolis taken withAbciximab it can increase the severity of bleeding.

CDSCOAPPOVAL: Cilostazol E.R. 100mg and 200 mg tablets are approved byCDSCO in India in30.10.2007.

FORMULATIONSAVAILABLE INMARKET:

Cilostazoletablets 50mg(E.R. release)

Cilostazoletablets 100mg(E.R. release)

Cilostazol+L-Carnitine100mg tablets

Note: Product protected by valid patents arenot offered for sale in countries where such patents are still valid and itsliability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult