Norethindroneis a hormonewhich is used in the treatment of hormone therapy and many gynaecologicaldisorders. A Norethindrone also used in the birth control pills, uterinebleeding and secondary amenorrhea.
SYNONYMS: 19-nor-ethindrone, 19-norethisterone,Norethindrone, Norethisteron, N, réthistérone, Norethisterone, Norethisteronum,Noretisterona
IUPAC NAME:(8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
CAS NO: 68-22-4
FORMULA: C20H26O2
MOLECULAR MASS: 298.42 g/mol
STORAGE CONDITION: Store in room temperature, away fromexcessive heat and sun light. Do not put in bathroom or kitchen. Keep away fromchildren and pets.
HOW TO USE: Take medicine by mouth with or without food. Takemedication one time per day for 15days. Ask to your doctor if you have anyconfusion.
HOW NORETHINDRONE WORKS: Norethindrone is the synthetic progestin.Norethindrone targets the progesterone receptors which are found in CNS,breasts, pituitary gland. By activating them Norethindrone increases secretionof hormones and treat the menstrual problem in female.
PHARMACOKINETICS OF NORETHINDRONE:Norethindronerapidly absorbed after the oral administration, the absolute bioavaibility ofthe drug is 64%. This drug binds with approx. 38% of sex hormones and 61% ofalbumin. The half-life of Norethindrone is between 8-10 hours. Almost 50% oforal dose eliminated by urination and remaining eliminated through the feces.
SIDE EFFECTS OF NORETHINDRONE: The common side effects are nausea, vomiting,headache, insomnia, swelling of breasts, acne, hair loss, weight gain etc. Contactyour doctor if you see side effects like vaginal bleeding, painful urination,vaginal discharge, irritation, and mood swings dark patches in skin, face. Seekimmediate doctor attention if you see side effects like blurred vision, slurredspeech, throat swelling, loss of vision, dizziness, pausing in arms , weaknessetc.,
PRECAUTIONS: Tell your doctor if you are allergic toNorethindrone. If you have problem related heart, liver, kidney, bloodcirculation, cancer, bleeding in brain or vagina tell your doctor about it. Thisdrug makes you dizzy and also effects of mood so kindly handle that type ofsituation.
CDSCO APPROVAL: Norethindrone acetate approved by CDSCO inIndia in June-1961
Trinovum (triphasic oral contraceptive) approved by CDSCO in Indiain January-1988
Norethindrone-1mg + Mestranol-0.05mg approved by CDSCO in India insepember-1970
FORMULATIONS AVAILABLE IN MARKET:
Norethindrone acetate 5 mg tablets
Norethindrone acetate 10mg tablets
Norethindrone acetate 15mg tablets
Norethindrone 5mg tablets
Norethindrone acetate 200mg/ml solution
Note: Product protected by valid patents are not offeredfor sale in countries where such patents are still valid and its liability isat Buyers Risk.
REFERENCES:
www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult
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