METOCLOPRAMIDE

Product Description

is one type of  medication used relieve symptoms caused by slow stomach emptying in peoplewho have diabetes. These symptoms include nausea, vomiting, heartburn, loss ofappetite, and feeling of fullness that lasts long after meals. 

SYNONYMS: Cerucal, Dihydrochloride,Metoclopramide, Hydrochloride, Metoclopramide, Maxolon,Metaclopramide,Metoclopramide,Metoclopramide Dihydrochloride.

IUPAC NAME: 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide

CASNO: 364-62-5

FORMULA: C₁₄H₂₂ClN₃O₂

MOLECULARMASS:299.8 g/mol

STORAGEOF METOCLOPRAMIDE:Store at 20 to 25C (68 to 77F). [See USP Controlled Room Temperature.]Protect from light by retaining in package until time of use. This product islight sensitive.

APPLICATIONSOF METOCLOPRAMIDE:Metoclopramide is adopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal refluxdisease or diabetic gastroparesis by increasing gastric motility. It is also used to control nausea and vomiting inchemotherapy patients.

AdultsAt first, 10 to 15 milligrams (mg) fourtimes a day, taken 30 minutes before symptoms are likely to begin or beforeeach meal and at bedtime, for 4 to 12 weeks.Your doctor may adjust your dose as needed. However, the dose is usually notmore than 60 mg per day.

HOW METOCLOPRAMIDE WORKS: It worksby increasing the movements or contractions of thestomach and intestines. It relieves symptomssuch as nausea, vomiting, heartburn, a feeling of fullness after meals, andloss of appetite. Metoclopramide is also used to treat heartburn for patientswith gastroesophageal reflux disease (GERD).

CONTRAINDICATIONS OF METOCLOPRAMIDE: Known hypersensitivity to metoclopramide orexcipients[44], Gastrointestinal bleeding, Obstruction, Perforation[30].

PHARMACOKINETICSOF METOCLOPRAMIDE: Bilastine has linear pharmacokinetics in the 2.5220 mg dose range in healthy adultsubjects without evidence of accumulation after 14 days of treatment.

SIDE EFFECTS OF METOCLOPRAMIDE:  The onset of pharmacological action of metoclopramideis 1 to 3 minutes following an intravenous dose, 10 to 15 minutes followingintramuscular administration, and 30 to 60 minutes following an oral dose;pharmacological effects persist for 1 to 2 hours. Metoclopramide is rapidly andwell absorbed.

PRECAUTIONS: Thismedicine may make you dizzy, drowsy, or have trouble with thinking orcontrolling body movements. Do not drive or doanything else that could be dangerous until you know how this medicine affectsyou. This medicine may cause tardive dyskinesia(a movement disorder).

CDSCO APPROVAL:

Metoclopramide C.R Tablets are approved by CDSCO in India in 13/04/1992

FORMULATION AVAILABLE IN MARKET:

Metoclopramide (as HCl) 200mg/400mg per ml IntranasalSolution

Metoclopramide C.R Tab.(metoclopramide hcl IP eq.to15mg of the anhydrous substance)

metoclopramide-5mg, dimethylpolysiloxane-250mg

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult