LEFLUNOMIDE

Product Description

Niksan Pharmaceutical is leading manufacturer and distributer of the Leflunomide among the other countries. Niksan Pharmaceutical is one of the major the supplier, distributer, exporter and manufacturer of the Leflunomide API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier, manufacturer, exporter and trader of Leflunomide in the domestic level as well as the international market.

Niksan Pharmaceutical provides Leflunomide API in all over Indian states like Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, Andhra Pradesh, Rajasthan, Meghalaya, Mizoram, Nagaland, Orissa, Pondicherry, Dadra and Nagar Haveli, Goa, Gujarat, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Leflunomide API and finished formulations in all other countries of the world like Germany, Switzerland, Poland, Latvia, Egypt, Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus, Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan, Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium, Saudi Arabia, Turkey, Japan etc.

Leflunomide is in a class of medications calleddisease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.

SYNONYMS: Leflunomida, Leflunomide, Lflunomide, Leflunomidum

IUPAC NAME: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

CAS NO: 75706-12-6

FORMULA: C₁₂H₉F₃N₂O₂

MOLECULAR MASS: 270.2073 g/mol

STORAGE OF LEFLUNOMIDE: Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

APPLICATIONS OF LEFLUNOMIDE: Leflunomide is a medication used in themanagement and treatment of rheumatoid arthritis. It is in the non-biologicalDMARDsclass of medications.

HOW TO USE: Leflunomideusually is given as a 20 mg tablet once a day. Sometimes, patients are given 10 mg, especially if they experienced side effects with the higher dose. Leflunomide should be taken with food. Complete benefits may not be experienced until 612 weeks after starting the medication.

HOW LEFLUNOMIDE WORKS:Leflunomide is used to relieve symptoms caused by active rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain. This medicine works bystopping the body from producing too many of the immune cells that are responsible for the swelling and inflammation.

CONTRAINDICATIONS OF LEFLUNOMIDE: Leflunomide is contraindicated insevere hepatic impairment due to hepatotoxicity. Other contraindications include hypersensitivity, previous or current skin reactions, immunosuppression, and impaired bone marrow function.

PHARMACOKINETICS OF LEFLUNOMIDE: Approximately 90% of a single dose of leflunomide is eliminated, 43% in urine, primarily as leflunomide glucuronides and an oxalinic acid derivative. Leflunomide is a prodrug that israpidly and almost completely metabolized following oral administrationto its pharmacologically active metabolite.

SIDE EFFECTS OF LEFLUNOMIDE: In some cases, Bloody or cloudy urine, cough, difficult or painful, breathing, difficult, burning, or painful urination, dizziness, fever, frequent urge to urinate, headache.

PRECAUTIONS: Blood or bone marrow problems, history of or-Bone marrow dysplasia or.Immune systemproblem or.Infection, severe or uncontrolled or.Tuberculosis, history of or.Weak immune systemUse is not recommended in patients with these conditions.

CDSCO APPROVAL:

Leflunomide tablets are approved by CDSCO in India in 01/10/2001

FORMULATION AVAILABLE IN MARKET:

Leflunomide (10mg/20mg/100mg)

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult