BACLOFEN IP

Product Description

Niksan Pharmaceutical is one of the biggest manufacturer, supplier, exporter and trader of the BACLOFEN finished formulations moreover Baclofen API. Niksan Pharmaceutical is the huge manufacturer, exporter and supplier of Baclofen API and formulation situated in Ankleshwar, Gujarat, India.

Niksan Pharmaceutical is the suppliers, manufacturer, exporters and trader of
Baclofen in the domestic level as well as the international market.

Niksan is an Indian based pharmaceutical company so it also supplies and manufactures the Baclofen to all Indian states like Gujarat, Maharashtra, Punjab, Delhi, Tamilnadu, Goa, Uttar Pradesh, Karnataka, Jammu & Kashmir, West Bengal, Assam, Rajasthan, Hyderabad, Karnataka, Kerala, Madhya Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Orissa, Punjab and Haryana.

Niksan Pharmaceutical and Niksan group companies are exporters, suppliers and manufacturers of the API and also Baclofen formulations in many countries for many years. Niksan pharmaceutical currently exports Baclofen API and Formulation to countries like New Zealand, Jordan, Belgium, United Kingdom, Australia, Italy, Ireland, Hong Kong, Morocco,, Portugal, France, South Africa, Philippines, Malaysia, Singapore, Israel, Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, South Korea, Switzerland, Algeria, Pakistan, Canada, Vietnam, United States, Germany, Brazil and many other countries.

BACLOFEN is a centrally acting skeletal muscle relaxant and antispastic agent. It is primarily used to treat spasticity from multiple sclerosis, spinal cord injuries, or other neurological disorders. It may also be prescribed off-label for alcohol use disorder and other conditions.

SYNONYSMS: Lioresal

IUPAC NAME: 4-amino-3-(4-chlorophenyl)butanoic acid

CAS NO: 1134-47-0

FORMULA: C10H12ClNO2

MOLECULAR MASS: 213.66 g/mol

STORAGE CONDITIONS: Store at room temperature (20C to 25C). Protect from light and moisture. Store in a tightly sealed container in a cool, dry place.

HOW TO USE: Baclofen is typically taken orally, with or without food. The usual starting dose is 5 mg taken three times daily. The dose may be gradually increased under a doctor's supervision to a maximum of 80 mg per day, depending on therapeutic response.

HOW BACLOFEN WORKS: Baclofen works by activating GABA-B receptors in the brain and spinal cord, which inhibits the transmission of nerve signals causing muscle spasticity. It reduces involuntary muscle stiffness and spasms, improving mobility and function.

PHARMACOKINETICS OF BACLOFEN: Baclofen is rapidly absorbed from the gastrointestinal tract, with peak plasma levels occurring in 23 hours. It is partly metabolized in the liver and excreted primarily via the kidneys. The half-life is about 26 hours.

SIDE EFFECTS OF BACLOFEN: The normal side effects caused by Baclofen are Drowsiness, Dizziness, Weakness, Fatigue, Nausea, Headache, Hypotension (low blood pressure), Rarely: confusion, seizures (in withdrawal), hallucinations.

PRECAUTIONS: Avoid abrupt discontinuation to prevent withdrawal symptoms. Use with caution in patients with renal impairment, epilepsy, or psychiatric conditions. Avoid alcohol and CNS depressants while on Baclofen. Dose adjustments may be needed in elderly patients.

CDSCO APPROVAL:

Baclofen ER (GRS) Capsule 45mg/60mg (additional strength) 22.02.07

Baclofen tablets 29/09/1995

Baclofen ER Capsule 10 mg/50 mg. (Additional Strength) 17.02.11

Baclofen E.R capsule (30mg) 01/08/2006

FORMULATIONS AVAILABLE IN MARKET:

BACLOFEN 10 MG tablets

BACLOFEN 25 MG tablets

BACLOFEN ORAL SUSPENSION

BACLOFEN INJECTION

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult