AL LOPURINOL

SYNONYMS: 2-deoxyphenobarbital, Primidon, Primidona, Primidone, Primidonum

 

IUPAC NAME: 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione

 

CAS NO: 125-33-7

 

FORMULA: C₁₂H₁₄N₂O₂

 

MOLECULARMASS:218.25 g/mol

 

STORAGE OF PRIMIDONE : Store the medicine in a closed container at roomtemperature, away from heat, moisture, and direct light. Keep from freezing.

APPLICATIONSOF PRIMIDONE:Primidone is used alone or with other medications to control certain types of seizures.Primidone is in a class of medications called anticonvulsants. It works bydecreasing abnormal electrical activity in the brain.

It is usually taken 3 to 4 times a day.

PRIMIDONE WORKS: Primidone isused alone or with other medications to control certain types of seizures.Primidone is in a class of medications called anticonvulsants. It worksby decreasing abnormal electrical activity in thebrain.

PRIMIDONE: Primidone is contraindicated in patients who are known to behypersensitive to barbituric acid derivatives. Contraindications to primidoneinclude patients with a history of porphyria. By inducing the enzymesresponsible for porphyrin synthesis, barbiturates may worsen acute porphyria.

PHARMACOKINETICSOF PRIMIDONE: Primidone is well absorbed and distributed throughout the body. Maximum plasma concentration is reached in about 2 h afteradministration of a 250 mg tablet. Primidone is metabolized in the liver toactive metabolites: phenobarbital and phenylethylmalonic acid (PEMA).

 

SIDE EFFECTS OF PRIMIDONE:  The most common sideeffect of primidone therapy is sedation and drowsiness. Ataxia, diplopia,and nystagmus occur at the initiation of treatment. Other adverse reactionsinclude dizziness, vertigo, epigastric pain, megaloblastic anemia, respiratorydepression, polyuria, skin rash, facial edema.

PRECAUTIONS: Check with your doctor before taking any of the above while you areusing this medicine. Primidone may cause some people to become dizzy,lightheaded, drowsy, or less alert than they are normally. Even if taken atbedtime, it may cause some people to feel drowsy or less alert on arising.

CDSCO APPROVAL:

Primidone tablet 50mg are approved by CDSCO in India in 15.04.2019

 

FORMULATION AVAILABLE IN MARKET:

Primidone12.5mg tablet

Primidone25mg tablet

Primidone50mg tablet

Primidone100mg tablet

Primidone250mg tablet

 

Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk

 

REFERENCES:

 

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult

Based on our expertise in the pharmaceutical industry, we are highly known as one of the leading manufacturers, exporters and suppliers of the 3-Amino Crotonicacid Cinnamyl Ester in Ankleshwar, Gujarat, India, as well as worldwide. It is widely appreciated by all our clients, situated all over the nation. Cilnidipine is primarily made from 3-Amino Crotonicacid Cinnamyl Ester. Niksan Pharmaceutical offers the most competitive price for it.

Synonym: Cinnamyl 3-Aminocrotonate, 3-Amino Crotonic Acid Cinnamyl Ester

• Chemical Name: 3-AMINO CROTONICACID CINNAMYL ESTER
• Description: White to yellow clear liquid
• CAS No: 103909-86-0
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.26
• Application : Used in Cilnidipine
  

NiksanPharmaceuticalprovides APIand finished formulations ofCilostazolin allover Indian States Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh,Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam,Punjab, Delhi, Bihar, Jammu Kashmir Etc.

Niksanpharmaceuticalis alsolarge exporter of the API and finished pharmaceutical products ofCilostazolin manycountries for years. The countries where we exporting are Puerto Rico, Brazil,Honduras, Argentina, Nicaragua, Philippines, Colombia, Guatemala, Uruguay,Mexico, Chile, Dominican Republic, Panama, South Korea, United States, ElSalvador, Venezuela, Taiwan, Indonesia, Bolivia, Peru, Ecuador, Romania, Hong Kong,Thailand, United Arab Emirates, Iraq, Serbia, Spain, Bulgaria, Greece,Pakistan, Hungary, Portugal, Vietnam, Egypt, Iran, Poland, chia, Germany,Malaysia, Saudi Arabia, Canada, United Kingdom, Australia, Japan, Turkey, Italyand many more countries.

Cilostazolis belongs to drugs classcalledplatelet-aggregation inhibitors. It is works by improving bloodflow in legs. Cilostazol is anti-platelet type of drug and it also used asvasodilator.

Cilostazolstops blood cells to combine or sticktogether and inhibits blood clots. Cilostazol is used to increase the bloodflow because of that the Oxygen flow in body also increases. Cilostazol is onetype of vasodilators so it is also helps blood to flow smoothly in body.

SYNONYMS:Cilostazol,Cilostazole, Cilostazolum

IUPAC NAME:6-[4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy]-1,2,3, 4-tetra hydro quinolin-2-one

CAS NO:73963-72-1

FORMULA:C₂₀H₂₇N₅O₂

MOLECULRMASS:369.46 g/mol

STORAGE:Store it in cool and dry place, away from moistureand direct light. Does not store this medicine in bathroom or any humidly place.Keep medicine away from the reach of children and pets.

APPLICATIONS:Cilostazolis widely used as vasodilator.Cilostazolisalso use in the treatment of intermittent claudication.Cilostazolalsouse to treat cramp, ache, fatigue, classically it is used in calf muscle duringthe workout.

HOW TO USE:Follow all directions on your prescriptionlabel or as your doctor recommends you. Take Cilostazol two times per day on anempty stomach. Take medicine at least 45 minutes or 2 hours before meal.Cilostazoltakes time like 8-12 weeks to improve yoursymptoms. But if your symptoms do not improve after 3-4 weeks treatments tellyou doctor. Try to take medicine at a same time each day to improveeffectiveness.

HOWCILOSTAZOL WORKS:Cilostazolmetabolites are one type of phosphodiesteraseIII inhibitors (PDA III inhibitors).Cilostazolinhibits activity of phosphodiesterase and also quash CAMP degradationso by that CAMP increased in Blood vessels and platelets and by this activitythe platelet degradation inhibits and also blood clotting reduced by theactivity

CONTRAINDICATIONS:Do not take Cilostazol medicati on if youhave any heart problems like Congetive heart failure. Take your doctors adviceif you are pregnant or in lactation phase.Cilostazolcan harm nursing baby so do not take medication if you are breastfeedinga baby. Do not share your medication with other person. Take your doctors recommendationif any adverse reactions appear while taking the treatment ofCilostazol.

PHARMACOKINETICS:AbsorptionofCilostazolin gastrointestinal system is slow orincomplete.Cilostazolis absorbed after the oral administration. Ahigh fa meal can increase the absorption ofCilostazol. Thehalf-life of theCilostazolis between11-13 hours. TheCilostazolexcreted almost 74-76% by urination and theremaining medicine 23-27% eliminate by the faces like sweating or by skin.

SIDE EFFECTSOFCILOSTAZOL:The common side effects ofCilostazolare headache, upset bowel movements, runnynose, normal rash, dizziness. There are some major side effects are also causeby theCilostazollike difficulty in breathing, chest pain, swellingof (face, tongue, fingers, and throat). Take your doctors instructions at theminute if you have symptoms like Fever, chills, body aches, flu symptoms.Paining while urinating or bloody urine Shortness of breath, swelling of feetand fingers Chest pain, irregular heartbeats.

PRECAUTIONS:Do not takeCilostazolif you have heart problem.Cilostazolcan make your problem worst. For the safetytell your doctor if you have any problem related liver or kidney. Avoid grapefruitjuice or product. Do not takeCilostazolwith Batcaver it can increase the serum level.IfCilostazolistaken withAbciximab it can increase the severity of bleeding.

CDSCOAPPOVAL:CilostazolE.R. 100mg and 200 mg tablets are approved byCDSCO in India in30.10.2007.

FORMULATIONSAVAILABLE INMARKET:

Cilostazoletablets 50mg(E.R. release)

Cilostazoletablets 100mg(E.R. release)

Cilostazol+L-Carnitine100mg tablets

Note:Product protected by valid patents arenot offered for sale in countries where such patents are still valid and itsliability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult

Pharmaceutical Excellence and GMP Compliance

Niksan Pharmaceutical delivers Cilostazol IP & USP formulations with strict adherence to GMP guidelines. We provide an unbroken chain of quality manufacturing, regular quality control checks, and well-maintained DMF documentation for seamless regulatory compliance. Our facilities guarantee top-notch standards for global pharmaceutical needs.


Versatile Dosage and Formulation Options

Our Cilostazol products are available as tablets (50 mg, 100 mg), capsules, and in raw powder form, ensuring flexibility and suitability for various applications. All products maintain high purity, optimal particle size, and are ideal for manufacturing cardiovascular and antihypertensive agents.


Proven Therapeutic Benefits

Cilostazol is widely recognized for its efficacy in managing intermittent claudication relating to peripheral vascular disease, supporting improved mobility and comfort for patients. Its precise structural formula ensures reliable pharmacological action and consistent results in clinical settings.

anantagonist of the NMDA (N-Methyl-D-Aspartate)-receptorsubtype of glutamate receptor. It is used toslow the neurotoxicity thought to be involved in Alzheimer disease and otherneurodegenerative diseases.

Memantina, Memantine, Memantinum

 

IUPAC NAME: 3,5-dimethyladamantan-1-amine

 

CAS NO: 19982-08-2

 

FORMULA: C₁₂H₂₁N

 

MOLECULAR MASS:179.30 g/mol

 

STORAGE OF MEMANTINE:Keepthis drug at a temperature between 59°F and 77°F (15°C and 25°C). Keep this drug away from light and high temperature.Don't store this medication in moist or damp areas, such as bathrooms.

 

APPLICATIONS OF MEMANTINE Memantine is amedication that comes in a tablet form. It treats dementia caused by Alzheimer's disease. Dementia affects your thinking, memory, reasoning,personality, mood and behavior. 

HOW TO USE: Memantine comes as a tablet, a solution(liquid), and an extended-release (long-acting) capsule to take by mouth. Thesolution and tablet are usually taken once or twice a day with or without food.

MEMANTINE WORKS: Memantineworks by blocking theeffects of a chemical called glutamate.Glutamate sends messages between nerve cells in the brain. Nerve cells damagedby Alzheimer's disease make too much glutamate which can cause more damage.Memantine protects nerve cells by blocking the effects of too much glutamate.

MEMANTINE: Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys thememory and the ability to think, learn, communicate and handle dailyactivities). Memantine is in a class of medications called NMDA receptorantagonists. It works by decreasing abnormal activity in the brain.

MEMANTINE: Memantine is wellabsorbed after oral administration and has linear pharmacokinetics over the therapeutic dose range. It is excreted predominantly in the urine, unchanged,and has a terminal elimination half life of about 60-80 hours.

MEMANTINE:  Memantine is not a cure for dementia butit can help with symptoms like being forgetful, feeling confused or feelinganxious. The most common side effects of memantine are feeling sleepy or dizzy, headaches, nervousness,pounding in the ears, constipation and shortness of breath.

 

PRECAUTIONS: This medication contains memantine, Do nottake Namenda XR or Namenda if you are allergic to memantine or any ingredientscontained in this drug.Keep out of reach of children, In case of overdose, getmedical help or contact a Poison Control Center immediately.

 

CDSCO APPROVAL:

Memantine hcl tablets are approved by CDSCO in India in 22/07/2004

 

FORMULATION AVAILABLEIN MARKET:

Memantine hcl tabs.

Memantine HCl ER Tablet 28mg

Memantine ER Tablet 7mg/14mg/21mg.

Memantine 5mg /10mg + Donepezil 5mg Tablets

 

Note: Product protected by validpatents are not offered for sale in countries where such patents are stillvalid and its liability is at Buyers Risk

 

REFERENCES:

 

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult

 

Minoxidil is belongs to the antihypertensive agent. It is used in the treatment of hypertension. Minoxidil comes in a solution and foam form which is used in the treatment of malepattern baldness (hair growth)

SYNONYMS: Minossidile, Minoxidil,Minoxidilum.

IUPAC NAME:2,6-diamino-4-(piperidin-1-yl) pyrimidin-1-ium-1-olate

CAS NO: 38304-91-5

FORMULA: C9H15N5O

MOLECULAR MASS: 209.25 G/MOL

STORAGE CONDITIONS: Store in cooland dry place. Remember this product is flammable so do no put it near the flames or in kitchen. Keep it away from the reach of the children and pet.

HOW TO USE: Read the instruction given on the label. First wash and clean the scalp area where the Minoxidil solution has to apply. To use the Minoxidil foam first wash your hand with water and dry well your hands and then gently apply the foam on the scalp andmassage for 5 to 10 minutes.

HOW MINOXIDIL WORKS: The full mechanism of Minoxidil is not known completely, thus Minoxidil is vasodilator Minoxidil relaxes the blood vessels and by this more oxygen cells will reach tothe hair follicles. And by this process hairs gain nutrition by the body.

PHARMACOKINETICS OF MINOXIDIL: Minoxidil is applied by the skin so the absorption of  is done by the skin. Minoxidil works by activating the extracellular signal-regulated kinase (ERK) and Akt and also prevents the death of cells. The half-life of Minoxidil is about 22hrs. Almost97% of Minoxidil and its residues are excreted by the urination only 3% will beexcreted by faeces.

SIDE EFFECTS OF MINOXIDIL: Theside effects of Minoxidil are burning redness and stinging are shown in thepatients. If you see some side effects like unwanted facial or body hairs,chest pain, irregular heart beats, fainting or dizziness contact your doctor. There are some rare side effects like rash, itching or swelling of skin areshown in some patients.

PRECAUTIONS: Before using theproduct tell your doctor if you have any disease of scalp, hear problem, chestpain, or have any allergic reaction to the Minoxidil. This product is takenclearly when it is needed during the pregnancy period.

CDSCO APPROVAL: Minoxidil topicallotion is approved by CDSCO in India in may-1988, Minoxidil Topical Solution 5%is approved by CDSCO in India in 16.05.2002

FORMULATION AVAILABLE IN MARKET:

Minoxidil 2%w/v solution

Minoxidil 5% w/v solution

Minoxidil 10%w/v solution

Minoxidil 5mg tablets

Minoxidil 10 mg tablets

Minoxidil 3%w/v solution

Minoxidil 10% w/w

Minoxidil 5% + Finasteridine2.5%w/v gel

Minoxidil 5%w/v +Finasteridine0.1%w/v gel

Note: Product protected by valid patents are not offered for sale in countries where such patents are still validand its liability is at Buyer Risk

 

 

Versatile Applications

Minoxidil serves a dual purpose, being effective both for promoting hair regrowth and managing hypertension. It comes in solution, foam, tablet, and capsule formats, making it suitable for topical or oral use as prescribed. This versatility ensures that patients receive the most appropriate treatment tailored to their condition and preferences.


Stringent Manufacturing and Quality

Manufactured and distributed by Niksan Pharmaceutical, Minoxidil is produced in a GMP-certified facility, ensuring high standards of purity and consistency. Each batch undergoes rigorous quality checks, guaranteeing a product of 99.98% purity. The medicine also comes with a ready DMF, underscoring its regulatory compliance for export and international acceptance.


Proper Usage and Storage Guidelines

For optimal results, tablets and capsules should be taken as prescribed. For topical application, first clean the scalp thoroughly before applying the solution or foam, gently massaging the area for 5 to 10 minutes. Always store Minoxidil in a cool, dry place, away from flames or heat sources, and ensure containers are well closed to maintain product integrity.

NIiksan Pharmaceuticalis the worlds leading pharmaceutical company in the field of manufacturing, supplying and exporting ofLoperamideand API. Niksan pharmaceutical provides wide range of API and Finished pharmaceutical products of Loperamide to the Niksan group companies and also to our customers in very affordable price.

Niksan Pharmaceuticalare the manufacturer, supplier andexporter of theLoperamidein domestic and as well as world wide.

Niksan Pharmaceuticalare manufacturing and supplyingLoperamidein the all over the Indian states like Punjab, Tamil nadu, Gujarat, Delhi , Uttar Pradesh, Bihar, Rajasthan, Maharashtra, west Bengal, Assam, Odisha.

Niksan Pharmaceuticalmanufacture and exports large quantity ofLoperamideamong the other nations from many years like Zimbabwe, Philippines, Tanzania, Singapore, Cambodia, Nepal, Ghana, Latvia, New Zealand, Kenya, Nigeria, South Africa, Netherlands, Puerto Rico, Indonesia, United Kingdom, France, United States, Canada, Moldova, Vietnam, Malaysia, Iraq, Sri Lanka, United Arab Emirates, Hong Kong, Jordan, Belgium, Australia, Ireland, Italy, Algeria, Pakistan, Thailand, Bangladesh, Taiwan, Saudi Arabia, Morocco, Israel, South Korea, Switzerland, Egypt, Iran, Romania, Sweden, Peru, Greece, Mexico, Spain, Colombia, Germany, Turkey, Poland, Japan, Braziland many other countries.

Loperamidecomes in the medicine class called antidiarrheal agents. Loperamide used in the treatment of diarrhoea and also use to controlthe frequency of diarrhoea. Loperamide is also used in theinfla amatory bowel disease and short bowl syndromes.

SYNONYMS:Loperamid, Loperamida, Loperamide, Loperamidum.

IUPAC NAME:4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

CAS NO:53179-11-6

FORMULA:C₂₉H₃₃ClN₂O₂

MOLECULAR MASS:477.04 g/mol (513.51 with HCl)g/mol

STORAGE CONDITION:Store medication at room temperature in dry place.Put it away from light and excessive heat. Do not put medication in bathroom orin kitchen. Keep it away from the range of children and pet.

HOW TO USE LOPERAMIDE:Take the medicine by mouth after each loose stool. The dosage form might be different in children and adult. Do not take more than 8 mg dose in 24 hours. If you are taking the chewing tablet of Loperamide take itin empty stomach. Ask for your doctors advice if needed.

HOW LOPERAMIDE WORKS:Loperamide decrease the flow of liquid and electrolyte tothe bowel, by doing this the bowel movement becomes slow by this the bowel movement will be decrease.

PHARMACOKINETIKCS OFLOPERAMIDE:Loperamide plasma concentrations will reach highest in 5hrs after taking the capsules and administration of liquid make it fast in approx. 2.5 hrs. The half-life of Loperamide is average 9.5-11.5 hrs. Loperamide binds with approximately 97% of plasma. The excretion of Loperamide is mostly done by faces.

SIDE EFFECTS OFLOPERAMIDE:The common side effects like dizziness, drowsiness, weakness. If taken in more quantity it can cause constipation also. Stop taking medicine if you see some side effects like nausea, vomiting, stomach pain, constipation, fast irregular heart beats. The allergic reaction of this drug is rare but if you find effects like rash/itching, irritation tell your doctor about it.

PRECAUTIONS OFLOPERAMIDE:If you are taking therapidly dissolving tablets keep your hand dry before taking medicine out of packet.Place tablet in mouth wait for it to dissolve and the swallow it with saliva. Stop taking medicine if you see some side effects like nausea, vomiting, stomach pain, constipation, fast irregular hear beats. Tell your doctor if you have any allergic reaction with Loperamide.

CDSCO APPROVAL:Loperamide approved by CDSCO in India inOctober-1978,

Loperamide approved by CDSCO in India in December-1976,

FDC of Loperamide + simethicone tablet Loperamide approvedby CDSCO in India in 16.10.2001.

FORMULATION OF LOPERAMIDEAVAILABLE IN MARKET:

Loperamide 2mg tablets

Loperamide 2mg/5ml syrup

Loperamide 2mg with simethicone 125 mg tablets

Furazolidone 100mg +Loperamide 2mg tablets

Loperamide 2 mg + Norfloxacin 250mg tablets

Metronidazole 200mg + Loperamide 2mg + Dicyclomine 20mgtablets

Note:Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

Precise Control of Diarrhea

Loperamide is designed to quickly reduce the frequency and urgency of bowel movements associated with diarrhea. Whether for acute episodes or chronic conditions like inflammatory bowel disease, this medication delivers reliable relief, allowing individuals to maintain their daily activities with confidence. It is especially valuable for patients needing consistent symptom management.


Manufactured for Quality

Produced by Niksan Pharmaceutical, a trusted manufacturer, exporter, and supplier, Loperamide is made with attention to purity (99%) and pharmaceutical standards. Each batch is processed in a GMP-certified facility and comes with a ready DMF, ensuring safety and consistency for distribution worldwide.


Convenient Usage and Storage

This medication is simple to administertaken orally as a tablet or capsule after each loose stool. For safe use, it should be stored in a well-closed container at room temperature, away from moisture and direct light. The well-defined storage instructions maintain its effectiveness throughout its three-year shelf life.