is one of the biggest manufacturer, supplier, exporter and trader ofthe Granisetron finished formulationsmoreover GranisetronAPI. Niksan Pharmaceutical is the hugemanufacturer, exporter and supplier of GranisetronAPI and formulation situated in Ankleshwar, Gujarat, India.
NiksanPharmaceutical is the suppliers, manufacturer, exporters and trader of
Granisetron inthe domestic level as well as the internationalmarket.
NiksanPharmaceutical pharis an Indian based pharmaceutical company so it also suppliesand manufactures the Granisetronto all Indian states like Gujarat,Maharashtra, Punjab, Delhi, Tamilnadu, Goa, Uttar Pradesh, Karnataka, Jammu &Kashmir, West Bengal, Assam, Rajasthan, Hyderabad, Karnataka,Kerala, Madhya Pradesh, Manipur, Meghalaya, Mizoram, Nagaland, Orissa, Punjaband Haryana.
NiksanPharmaceutical and Niksan group companies are exporters, suppliers andmanufacturers of the API and also GRANISETRON formulations in many countries for many years. Niksanpharmaceutical currently exports Granisetron API and Formulation to countrieslike New Zealand, Jordan, Belgium, United Kingdom, Australia, Italy, Ireland,Hong Kong, Morocco,, Portugal, France, South Africa, Philippines, Malaysia,Singapore, Israel, Greece, Saudi Arabia, Egypt, Taiwan, Netherlands, SouthKorea, Switzerland, Algeria, Pakistan, Canada, Vietnam, United States, Germany,Brazil and many other countries.
GRANISETRON is in a class ofmedications called5-HT3receptor antagonists. It is used toprevent nausea and vomiting that may occur after treatment with cancermedicines (chemotherapy or radiation), including high-dose cisplatin. Thismedicine is also used to prevent and treat nausea and vomiting that may happenafter surgery.
SYNONYSMS:Granisetron Hydrochloride, Granisol, BRL-43694, Granisetronum
IUPAC NAME: 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
CAS NO:109889-09-0
FORMULA:C18H24N4O
MOLECULAR MASS: 312.41g/mol
STORAGE CONDITIONS:stored at room temperature under normallighting conditions.
HOW TO USE:Granisetron comes asa tablet to take by mouth.When taken to prevent nausea and vomitingcaused by chemotherapy, granisetron is usually taken 1 hour before chemotherapyis begun. A second dose may be taken 12 hours after the first dose depending onthe strength.
HOW GRANISETRONWORKS:Itworksby blocking serotonin, a natural substance in the body that causesnausea and vomiting.
PHARMACOKINETICSOF GRANISETRON:It is aserotonin5-HT3receptorantagonistused as anantiemeticto treatnauseaand vomiting followingchemotherapyand radiotherapy. Its main effect is to reduce the activity ofthevagus nerve, which is a nerve that activates the vomitingcenter in themedullaoblongata. It does not have much effect onvomiting due to motion sickness. This drug does not have any effect ondopaminereceptors ormuscarinic receptors.
SIDE EFFECTSOF GRANISETRON: The normal side effects caused by GRANISETRON are headache,stomach pain, heartburn, constipation, difficulty falling asleep or stayingasleep, fever, flu symptoms.
PRECAUTIONS: Tell yourdoctor if you are allergic to the medicine. Ask your doctors advice if youhave medical history like diabetes, heart problem, liver problem, kidneydisease, breast cancer or tumour. If you are taking the other medication kindlytell your doctor about it. Granisetron may causeallergic reactions, which can beserious. Stop using granisetron and get help right away if you have any seriousallergic reaction.
CDSCOAPPROVAL:GRANISETRON tablet (additional strength)Each filmcoated tablet contains; granisetron hcl eq.to granisetron-1mg,2mg, each ml ofinj.contains; granisteron hcl eq.to granisetron-1mg. 05/07/2000
FORMULATIONSAVAILABLE IN MARKET:
GRANISETRON 1 MG tablets
GRANISETRON INJECTION
Note: Productprotected by valid patents are not offered for sale in countries where suchpatents are still valid and its liability is at Buyers Risk
REFERENCES:
www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult
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