Niksan Pharmaceutical is the largest manufacturer and exporter of the Cilostazol among all over the world. Niksan Pharmaceutical is oneof biggest the supplier, manufacturer, exporter and distributer of the Cilostazol API and finishedformulations in Ankleshwar, Gujarat, India. The products ofNiksan Pharmaceutical and Niksan group companies are widely appreciated by theclients and other companies.
Niksan Pharmaceutical provides API and finishedformulations of Cilostazol in allover Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh,Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam,Punjab, Delhi, Bihar, Jammu Kashmir Etc.
Niksan pharmaceutical is also large exporter ofthe API and finished pharmaceutical products of Cilostazol in many countries for years. The countries where weexporting are Puerto Rico, Brazil, Honduras, Argentina, Nicaragua, Philippines,Colombia, Guatemala, Uruguay, Mexico, Chile, Dominican Republic, Panama, SouthKorea, United States, El Salvador, Venezuela, Taiwan, Indonesia, Bolivia, Peru,Ecuador, Romania, Hong Kong, Thailand, United Arab Emirates, Iraq, Serbia,Spain, Bulgaria, Greece, Pakistan, Hungary, Portugal, Vietnam, Egypt, Iran,Poland, Czechia, Germany, Malaysia, Saudi Arabia, Canada, United Kingdom,Australia, Japan, Turkey, Italy and many more countries.
Cilostazol is belongs to drugs class called platelet-aggregation inhibitors. It is works by improving blood flow inlegs. Cilostazol is anti-platelet type of drug and it also used as vasodilator.
Cilostazol stops blood cells to combine or stick togetherand inhibits blood clots. Cilostazol is used to increase the blood flow becauseof that the Oxygen flow in body also increases. Cilostazol is one type ofvasodilators so it is also helps blood to flow smoothly in body.
SYNONYMS: Cilostazol,Cilostazole, Cilostazolum
IUPAC NAME: 6-[4-(1-cyclohexyl-1H-1, 2, 3, 4-tetrazol-5-yl) butoxy]-1, 2,3, 4-tetrahydroquinolin-2-one
CAS NO: 73963-72-1
MOLECULR MASS:369.46 g/mol
STORAGE: Store it incool and dry place, away from moisture and direct light. Does not store this medicinein bathroom or any humidly place. Keep medicine away from the reach of childrenand pets.
APPLICATIONS: Cilostazol is widely used as vasodilator. Cilostazol is alsouse in the treatment of intermittent claudication. Cilostazol also useto treat cramp, ache, fatigue, classically it is used in calf muscle during theworkout.
HOW TO USE: Follow all directions on yourprescription label or as your doctor recommends you. Take Cilostazol two timesper day on an empty stomach. Take medicine at least 45 minutes or 2 hoursbefore meal. Cilostazol takes time like 8-12 weeks to improve your symptoms.But if your symptoms do not improve after 3-4 weeks treatments tell you doctor.Try to take medicine at a same time each day to improve effectiveness.
HOW CILOSTAZOL WORKS: Cilostazol and Cilostazol metabolitesare one type of posphodiesterase III inhibitors (PDA III inhibitors). Cilostazol inhibitsactivity of posphodiesterase and also quash cAMP degradation so by that cAMPincreased in Blood vessels and platelets and by this activity the plateletdegradation inhibits and also blood clotting reduced by the activity.
CONTRAINDICATIONS: Do not take Cilostazol medication if youhave any heart problems like Congestive heart failure. Take your doctorâsadvice if you are pregnant or in lactation phase. Cilostazol can harma nursing baby so do not take medication if you are breastfeeding a baby. Donot share your medication with other person. Take your doctorâs recommendation ifany adverse reactions appear while taking the treatment of Cilostazol.
PHARMACOKINETICS: Absorption of Cilostazol ingastrointestinal system is slow or incomplete. Cilostazol is absorbed after the oral administration. A high fatmeal can increase the absorption of Cilostazol. Thehalf-life of the Cilostazol is between 11-13 hours. The Cilostazol excretedalmost 74-76% by urination and the remaining medicine 23-27% eliminate by thefaces like sweating or by skin.
SIDE EFFECTS OF CILOSTAZOL: Thecommon side effects of Cilostazol are headache, upset bowel movements, runny nose,normal rash, dizziness. There are some major side effects are also cause by theCilostazol likedifficulty in breathing, chest pain, swelling of (face, tongue, fingers, andthroat). Take your doctorâs instructions at the minute if you have symptomslike Fever, chills, body aches, flu symptoms. Paining while urinating or bloodyurine Shortness of breath, swelling of feet and fingers
Chest pain, irregular heartbeats.
PRECAUTIONS: Do not take Cilostazol if youhave heart problem. Cilostazol can make your problem worst. For the safety tell yourdoctor if you have any problem related liver or kidney. Avoid grapefruit juiceor product. Do not take Cilostazol with Abacavir; it can increase the serum level. If Cilostazolis taken with Abciximab it can increase the severity of bleeding.
CDSCO APPOVAL: Cilostazol E.R. 100mg and 200mg tablets areapproved by CDSCO in India in 30.10.2007.
FORMULATIONS AVAILABLE IN MARKET:
Cilostazole tablets 50mg (E.R. release)
Cilostazole tablets 100mg (E.R. release)
Cilostazol +L-Carnitine 100mg tablets
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