DONEPEZIL

Product Description

is words top leading manufacturer, exporter, trader and supplier of DonepezilAPI as well as finished pharmaceutical products of Donepezilamong the pharmaceutical companies. Our product Donepezilis widely used and appreciated by our group companies and also ourcustomers and users all around the nations. We offer the Donepezilin very affordable price.

NiksanPharmaceutical provides API and finished formulations of Donepezil in all over Indian states Like Kerala, Gujarat, Haryana,Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Meghalaya,Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Jammu Kashmir Etc.

Niksan Pharmaceuticalis also large exporters of the API and finished pharmaceuticalproducts of Donepezil in manycountries for years. The countries where we exporting are Puerto Rico, UnitedStates, Finland, Ireland, New Zealand, Canada, United Kingdom, Belgium, Sweden,Australia , South Korea Austria, Hong Kong, Singapore, Germany, Philippines, Israel,Italy, Romania, Nigeria, Czechia, Denmark, Switzerland, Norway , Croatia,Greece, Taiwan, Malaysia, United Arab Emirates , Portugal, Poland, Thailand,Indonesia, Egypt , Iran, Hungary, Brazil, Saudi Arabia, Pakistan , SouthAfrica, France, Turkey, China, Vietnam , Netherlands, Mexico, Colombia, Spain,Japan and many more countries.

Donepezil is the medication used totreat the Alzheimer disease. Alzheimer disease is the condition which causesbrain cells to die or waste away and by this Alzheimer’s diseasecan cause mental disorders and loss of memory. Donepezil belongs to the cholinesterase inhibitorsclass of medicine.

SYNONYMS: Domepezil, Donepezil, Donepezilo,Donepezilum.

IUPAC NAME OF DONEPEZIL:  

CAS NO: 120014-06-4

FORMULA: C₂₄H₂₉NO₃

MOLECULAR MASS: 379.49 g/mol

STORAGE CONDITIONS: Store in cool and dry place away from themoisture and sun light. Do not place it in bathroom or humid place. Keep awayfrom children and pets.

HOW TO USE DONEPEZIL: Do not crush, chew or spit the medication.

HOW DONEPEZILWORKS: Donepezilused in the Alzheimer disease but Donepezil does not cure the disease it isonly improve the memory, awareness, and treat confusion. Donepezil inhibits theacetyl cholinesterase enzyme activity and by this process improves the mentalcondition and brain work.

PHARMACOKINETICS OF DONEPEZIL: Donepezil absorbed slowly by the GI trackafter the oral administration. Donepezil have 100% bioavaibility and reaches Tmax in 3-4 hours. Almost 96% of Donepezil binds with the plasmaprotein in the body. The half-life of Donepezil is very high. Donepezil hashalf-life of 70 hours. Almost 57% of Donepezil eliminated through the urinationand only 5% Donepezil eliminated in feces.

SIDE EFFECTS: The common side effects like nausea,vomiting, tiredness, shakiness, muscle cramps, weakness, trouble in sleeping,dizziness are seen in the patients. Tell your doctor if you have effects likeblack stool, vomit that look like coffee, stomach or abdominal pain, trouble inurination. The allergic reaction is very rare like rash, itching, swelling oftongue, face, trouble in breathing.

PRECAUTIONS: Tell your doctor your medical history if youhave intestinal disease like bleeding, trouble in urination, asthma, COPD<fainting, stomach disease etc. Do not take medicine if you are pregnant or inlactation period. This drug has dizziness effect so do not consume alcohol ormarijuana while completing the dose. Donepezil cause heart problems so kindlytake your doctor’s advice.

CDSCO APPROVAL: Donepezil (for additional indication)approved by CDSCO in India in 10.08.2005, Donepezil HCl. approved by CDSCO inIndia in 22.03.2001,

Donepezil Hydrochloride Orodispersible Tablet 5mg/10mg approved byCDSCO in India in 15.10.2009,

Memantine 5mg /10mg + Donepezil 5mg Tablets approved by CDSCO inIndia in 31.01.2008,

Donepezil Sustained Release Tablet 23mg (Modified Dosage Form)03.06.2011.

FORMULATION AVAILABLE IN MARKET:

Donepezil 5mg tablets

Donepezil 10mg tablets

Donepezil 23mg tablets

Donepezil 5mg + Memantine 5mg tablets

Donepezil 5mg + Memantine 10mg tablets

Donepezil Hydrochloride Orodispersible Tablets 5mg

Donepezil Hydrochloride Orodispersible Tablets10mg

Donepezil HCl tablet

Note: Product protected by valid patents are notoffered for sale in countries where such patents are still valid and itsliability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult