CLOSANTEL SODIUM

Product Description

Niksan Pharmaceutical is leading manufacturer and distributer of the Closantel Sodiumamong the other countries. NiksanPharmaceutical is one of the major the supplier, distributer, exporter andmanufacturer of the Closantel Sodium API and finished formulations in Ankleshwar, Gujarat,India. The products of Niksan Pharmaceutical and Niksan group companies arewidely appreciated by the clients and other companies.

Niksan Pharmaceutical is the supplier,manufacturer, exporter and trader of Closantel Sodium in thedomestic level as well as the international market. 

Niksan Pharmaceutical provides Closantel Sodium API in all over Indian states like Jammu & Kashmir,Himachal Pradesh, Uttarakhand, Punjab, Kerala, Chandigarh, Chhattisgarh, AndhraPradesh, Rajasthan, Meghalaya,Mizoram, Nagaland, Orissa,, Dadra and NagarHaveli, Goa, Gujarat,Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh etc.

Niksan Pharmaceutical also provides Closantel Sodium API and finished formulations in all othercountries of the world like Germany, Switzerland, Poland, Latvia, Egypt,Lithuania, Estonia, Ukraine, Moldova, Russia, United States, Austria, Belarus,Serbia, India, Spain, Slovenia, Nigeria, Croatia, South Africa, Kazakhstan,Italy, Romania, Bulgaria, Portugal, South Korea, Greece, Philippines, Belgium,Saudi Arabia, Turkey, Japan etc.

Closantel Sodium is one typeof synthetic anti parasitic agent which is highly effective against adults andlarvae (6 to weeks old) of liver flukes (Fasciola hepatica), and againstseveral important gastrointestinal roundworms.  

SYNONYMS: Closantel sodium, Closantel (sodium)

IUPAC NAME: sodium;2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylphenyl]carbamoyl]-4,6-diiodophenolate

CAS NO: 61438-64-0

FORMULA: C₂₂H₁₃Cl₂I₂N₂NaO₂

MOLECULAR MASS: 685.1  g/mol

STORAGE OF CLOSANTEL SODIUM:Store at roomtemperature.

APPLICATIONS OF CLOSANTEL SODIUM: Closantel is a synthetic anti parasitic agent which is highly effective against adults and larvae (6 to weeksold) of liver flukes (Fasciola hepatica), and againstseveral important gastrointestinal roundworms (e.g. Bunostomum, Haemonchus, Oesophagostomum,Ostertagia - Teladorsagia, Strongyloides, Trichostrongylus).

HOW TO USE:  5.25 g of closantel sodium, 1 g of hydroxypropylcyclodextrin and 0.5 g of povidone are dissolved in each 100 mL of the mixedsolvent.

HOW CLOSANTEL SODIUM WORKS: causes an initial burst of contractions of much greateramplitude and frequency than normal in tissue vessel, the stimulation of amplitude and frequency lasted for nearly 15 minand is accompanied by a rise in muscle tone, which reaches a maximum at 16 min,at a level greater than 1.5 times.

CONTRAINDICATIONS OF CLOSANTEL SODIUM: It is widely used in management of parasitic infestation inanimals but is contraindicatedin humans and in high dose in milk producing animals because of its secretion in milk.

PHARMACOKINETICS OF CLOSANTEL SODIUM:Rapidly absorbed into the systemic circulation with peak plasma levels at 24-48hours after dosing. In plasma, closantel isbound 99% to albumin.

SIDE EFFECTS OF CLOSANTEL SODIUM Its inhibitioninterrupts their development to adult worms. This drug possesses some sideeffects: hyperacute anaphylactic reactions in cattle; hypersensitivity reactions; overdosescan cause reduced visibility or blindness, anorexia, lack of coordination andgeneral weakness.

PRECAUTIONS:

P202 Do not handle until all safetyprecautions have been read and understood.

P260 Do not breathe mist or vapors. P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke whenusing this product.

CDSCO APPROVAL:

Closantel 15% Oral Solution  are approved by CDSCO in India in 3-10-1994

FORMULATION AVAILABLEIN MARKET:

Closantel sodium injection 5%

Closantel sodium injection 7.5%

Closantel sodium injection 10%

Note: Product protected by validpatents are not offered for sale in countries where such patents are stillvalid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult