CLOBETASOL PROPIONATE

Product Description

Niksan Pharmaceutical is one of the leading Manufacturer, Exporter, Distributor, andSupplier of Clobetasol Propionate in Ankleshwar, Gujarat, India. To understand the largestaccomplishment of clients, we present these products at very realistic priceranges. Niksan Pharmaceutical and Niksan group companies are now a days one ofthe largest manufacturer and exporter of Clobetasol Propionate API and alsofinished formulations.

 

Niksan Pharmaceutical provides Clobetasol Propionate to all states of India like Punjab, Rajasthan, Andhra Pradesh, Haryana,Telangana, Bihar, Karnataka, Delhi, Tamil Nadu, Odisha, Maharashtra, West Bengal,Uttar Pradesh, Gujarat, and Madhya Pradesh etc. We also give gift samples tothe companies for R&D purpose.

 

Niksan Pharmaceutical is one of leading manufacturer and exporter of Clobetasol Propionate for manyyears in all the countries like Puerto Rico, United States, Nepal, Philippines,Hong Kong, Nigeria, Bangladesh, United Arab Emirates, Pakistan, Taiwan,Singapore, Malaysia, Canada, Indonesia, Thailand, New Zealand, Vietnam, Israel,United Kingdome, Saudi Arabia, Chile, Australia, Colombia, France, Germany,Brazil and many other countries.

 

Clobetasol Propionate is class I corticosteroid medication. Clobetasol Propionate used in thetreatment of many skin diseases like skin rash, eczema, seborrheic dermatitis,psoriasis, contact dermatitis. Clobetasol Propionate is used in skininfections. Comes in many dosage forms like shampoo,cream, lotions, andointment

 

SYNONYMS: Clobetasol 17-propanoate, Clobetasol 17-propionate, Clobetasolpropionate, Clobetasol propionate E

 

IUPAC NAME:(1R,2S,10S,11S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1-fluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracycloheptadeca-3,6-dien-14-ylpropionate

 

CAS NO: 25122-46-7FORMULA: C₂₅H₃₂ClFO₅

 

MOLECULAR MASS: 466.97g/mol

 

STORAGE CONDITIONS: Store in cool and dry place, away from light and direct heat. Do notplace medicine in bathroom or humid place. Keep away from children and pets.

 

HOW TO USE: Do not use Clobetasol Propionate on face, under arms or onopen wounds. Wash and clean the affected area and after that apply a thin filmof Clobetasol Propionate gel on the area and gently rub it. Two time a day.

 

HOW CLOBETASOL PROPIONATEWORKS: Clobetasol Propionate bindswith the glucocorticoid receptor and inhibits the pro-inflammatory receptor.Clobetasol Propionate promotes the anti-inflammatory signals to the brain andgives inflammatory effects

 

PHARMACOKINETICS: Clobetasol Propionate absorbed systemic circulation after theapplication. Clobetasol Propionate takes 5 hours to reach the peak plasmaconcentration after using 2 times daily. The bioavailability of ClobetasolPropionate is only 2.09%. The half-life of Clobetasol Propionate is 96hours.The medicine metabolise in liver and after it will excrete by biliary rout.

 

SIDE EFFECTS: Normally burning, skin irritation, stinging, dry skin, redness myseen at the site where medicine was applied. Contact your doctor If you seesome side effects like stretch marks; skin tightening, acne, skin thinning, andunwanted hair grow. Some rare side effects like weakness, fainting, skinburning, rash, itching, weight loss, headache seen in patients.

 

PRECAUTIONS: Tell your doctor if you are allergic to the medication. If you havemedical history like weak immune system, skin problem, poor blood circulationproblem, liver problem tell your doctor before using the medication. The medicationcan temporarily slow down the child growth so take advice from doctor beforegiving to children. Do not use this medication if you are in pregnancy or inlactation period.

 

CDSCO APPROVAL: Clobetasol propionate + Ammonium lactategel is approved by CDSCO inIndia in 07.08.1996

Clobetasolpropionatecream/ointment approved by CDSCO in India in October-1987

Clobetasol propionate bulkapproved by CDSCO in India in October-1987

Nadifloxacin (1%) +Clobetasol (0.05%) approved by CDSCO in India in 06.10.2003

 

FORMULATIONS AVAILABLE INMARKET:

Clobetasol propionate 0.05%w/w cream

Clobetasol propionate 0.05%w/v solution

Clobetasol propionate0.025% w/w gel

Clobetasol propionate0.05%w/w + Clotrimazole 1%w/w cream

Clobetasol propionate 0.05%w/w + Miconazole 2%w/w cream

Clobetasol propionate0.05%w/w + Luliconazole 1% w/w cream

Clobetasol propionate0.05%w/w + Terbinafine 1% w/w cream

Clobetasol propionate0.05%w/w + Nadifloxacin 1% w//w cream

Clobetasol propionate0.05%w/w + Salicylic acid 3% w/w cream

Clobetasol propionate0.05%w/w+ Fusidic acid 2% w/w cream

Clobetasol propionate 0.05%w/v+ Salicylic acid 3%w/v gel

 

Note: Product protected by valid patents are not offered for sale incountries where such patents are still valid and its liability is at BuyersRisk

 

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult