GLIMEPIRIDE

Product Description

Niksan Pharmaceuticaland our group companies Niksan healthcare are the one of largestmanufacturer and supplier ofGlimepirideformulations and Glimepiride API in Ankleshwar, Gujarat, India. We aresupplying the best quality of Glimepiride API all around the India as well as inthe whole world. Our product Glimepiride praised by our clients and also by theother companies.

Niksan Pharmaceuticalis the worlds leading manufacturing and supplying company of theGlimepirideproducts and API. Thuswe areIndianbased company we supplying our best quality products to everystates of India for many years like Jammu and Kashmir, Kerala, Punjab, Rajasthan,Andhra Pradesh, Haryana, Telangana, Bihar, Karnataka, Delhi, TamilNadu, Odisha,Maharashtra, West Bengal, Uttar Pradesh, Gujarat, Madhya Pradesh, HimachalPradesh, Goa, Chhattisgarh etc.

Niksan Pharmaceutical also exports huge quantity of best qualityGlimepirideAPI products to theother nations likePuerto Rico,Indonesia,Nepal,Ghana,UnitedStates,Philippines,Jordan,Pakistan,Nigeria, Sri Lanka,United Arab Emirates, South Africa, Bangladesh, Netherlands, Taiwan, Iraq,Saudi Arabia, Venezuela, Hong Kong, Singapore, Vietnam, Egypt, South Korea, Algeria,Morocco, France, Israel, Australia, United Kingdom, Canada, Malaysia, Italy,Thailand, Colombia,Mexico, Argentina, Spain, Germany, Brazil, Japanand many south eastern countries.

Glimepirideis the type of drug which is used in the treatment of the type IIdiabetes mellitus. Glimepiride is basically the oral dosage form. With the dietand proper exercise and treatment of Glimepiride works more effectively.Glimepiride patented in year 1979 and then it is approved for the medical usein the year 1995.

Glimepiridecome in the sulfonylurea class of drug which acts by increasingthe body insulin which cause decrease in blood sugar.

SYNONYMS OF GLIMEPIRIDE: Glimepirida, , Glimepiride, Glimepiridum.

IUPAC NAME:3-Ethyl-4-Methyl-N-[2-(4-{[(trans-4-methylcyclohexyl) carbonyl]sulfonyl} phenyl) ethyl]-2-oxo-2, 5-dihydro-1H-pyrrole-1-Carboxamide

CAS NO:93479-97-1

FORMULA:C24H34N4O5S

MOLECULAR MASS:490.62g/mol

HOW TO USE:Read the leaflet of the Glimepiride. the medicine is only taken one timea day so take the medicine in morning orally with breakfast.to take the mostbenefit of Glimepiride take it regularly at a same time for days. If you arealready taking other diabetic medicines take your doctor is advice to how to usethe Glimepiride medication.

HOW GLIMEPIRIDEWORKS:Glimepiride main work is toreduce the blood sugar level by stimulating the insulin from pancreatic betacells. By this process the peripheral glucose uptake and by this the bloodsugar level decreased by the Glimepiride.

CONTRAINDICATIONS OFGLIMEPIRIDE: If you have any allergy,tell your doctor before taking these medicines and other inactive ingredientswhich can cause allergic reactions. Because of the action of the drug the bloodsugar level will decrease by this the blurred vision and drowsiness effects areseen so do not take this medicine while driving or doing any machinery workswhich can cause hazardous reaction. Do not go out in sun because this medicinecan make you sensitive to the sun.

PHARMACOKINETICS OFGLIMEPIRIDE:Glimepiride is takenorally and will easily absorb after the administration in 1 hour and reach theblood peak plasma concentration within 3 hours. The plasma protein binding ofGlimepirideis more than 99.5%. The drug will metabolise completely in liver.Basically the half-life of Glimepiride is 5-8 hours but it can increase bytaking multiple dosages. The excretion of Glimepiride is mainly (60%) done byurination and the other is done in feces.

SIDE EFFECTS OFGLIMEPIRIDE: The normal side effects ofGlimepiride are nausea and upset stomach. Contact your doctor if any sideeffect like weakness, yellowing of eye/skin, dark urine, bleeding, infections,mood swings occurs. The medicine cause loss of blood sugar so weakness in body,shaking of arms and feet, hunger, blurred vision, unconsciousness type ofeffects are seen in the patient. If you notice symptoms like rash, allergy,swelling of face, itching, and trouble in breathing contact your doctorimmediately.

PRECAUTIONS OFGLIMEPIRIDE: The medicine cause loss ofblood sugar so kindly avoids the heavy exercise. Do not drink alcohol it cancause low blood sugar level. Because Glimepiride reduce the blood sugar levelkindly avoids the activity like driving or exercising or operating heavymachineries. Discuss the medication plan with your doctor before taking themedication, and always take medicine in time.

CDSCO APPROVAL:Glimepiride 1mg/2mg/3mg/4mg tablets are approved by CDSCO in Indiain 24.01.1999.

Pioglitazone HCL +glimepiride tablet is approved by CDSCO in India in 25.10.2002.

Glimepiride + metformin SRtablet is approved by CDSCO in India in 13.11.2002.

Rosiglitazone + glimepiridetablet is approved by CDSCO in India in 14.11.2002.

Glimepiride + rosiglitazonetablet is approved by CDSCO in 12.12.2003.

FDC of Glimepiride(1mg/2mg) + Pioglitazone (15mg) + Metformin(500mg E.R) Tablet is approved byCDSCO in India in 12.08.2005.

Glimepiride 1mg/2mg. +Metformin SR 1000mg tablet (additionalstrength) is approved by CDSCO in08.06.2007.

FORMULATIONS AVAILABLE INMARKET:

Glimepiride 1mgtablets

Glimepiride 2mgtablets

Glimepiride 3mgtablets

Glimepiride 4mg tablets

Pioglitazone HCL +glimepiride tablets (15mg+1/2mg)

Glimepiride + metformin(1/2mg+500mg)

Rosiglitazone + glimepiride(2mg+1mg)

Glimepiride + rosiglitazone(1/2mg+30mg)

Glimepiride (1mg/2mg) +Pioglitazone (15mg) + Metformin (500mgE.R) Tablet

Glimepiride 1mg/2mg. +Metformin SR 1000mg tablet (additional strength)

Note:Product protected by valid patents are not offered for sale incountries where such patents are still valid and its liability is at BuyersRisk

REFERENCES:

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com

https://cdscoonline.gov.in

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult